Targeted synthesis and in vitro bactericidal and fungicidal activities of 2-alkylthio-5-(p-aminophenyl)-1,3,4-oxadiazoles.

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D Ismailova
A Ziyaev
B Elmuradov
T Toshmurodov
Kh Bobakulov
R Zakirova

Abstract

Selective alkylation of 5-(p-aminophenyl)-1,3,4-oxadiazol-2(3H)-thione with alkyl halides have been studied. It was revealed that alkylation goes on more polarized thiogroup in position 2 and corresponding 2-alkylthio-1,3,4-oxadiazoles were obtained in high yields. Structure of novel synthesized compounds confirmed by physical methods of research as UV-, IR- and 1H NMR-spectroscopy. Primary in vitro biological activity have been studied and it was found that all obtained S-alkyl derivatives have weak activity against bacteria Xanthomonas malvacearum and fungicidal activity against fungi Fusarium oxysporum.

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How to Cite
Ismailova, D., Ziyaev, A., Elmuradov, B., Toshmurodov, T., Bobakulov, K., & Zakirova, R. (2022). Targeted synthesis and in vitro bactericidal and fungicidal activities of 2-alkylthio-5-(p-aminophenyl)-1,3,4-oxadiazoles. Journal of Basic and Applied Research in Biomedicine, 2(4), 476–479. Retrieved from https://jbarbiomed.com/index.php/home/article/view/118
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Original Article