Synthesis and Study of Influence of the Methylene Group Quantity on the Structural Behavior of Polymethylene-Quinazolinethiones.

Authors

  • A Nasrullaev Organic Synthesis Department, Institute of the Chemistry of Plant Substances, Uzbek Academy of Sciences, Tashkent 100170, Uzbekistan.
  • K Turgunov Organic Synthesis Department, Institute of the Chemistry of Plant Substances, Uzbek Academy of Sciences, Tashkent 100170, Uzbekistan.
  • B Zhurayev National University of Uzbekistan, Chemical Faculty, Tashkent 100195, Uzbekistan
  • A Kadyrov Karshi State University, Kuchabagh str. 17, Karshi 180103, Uzbekistan
  • B Elmuradov Organic Synthesis Department, Institute of the Chemistry of Plant Substances, Uzbek Academy of Sciences, Tashkent 100170, Uzbekistan.

Keywords:

Quinazolinethiones, Methylene groups, Nucleophilicity, Hydrogen bonds, Conformational analysis, X-ray diffraction study.

Abstract

6,7,8,10-Tetrahydropyrrolo[2,1-b]quinazolin-10-thione (4), 6,7,8,9-tetrahydro-11H-pyrido[2,1-b] quinazoline-11-thione (5), and their seven-membered homologue - 6,7,8,9,10,12-hexahydroazepino[2,1-b]quinazolin-12-thione (6) have been synthesized by interaction of corresponding quinazolones (1-3) with phosphorus pentasulfide. First time the comparable X-ray crystal structure analysis of polymethylenequinazolinethiones (4-6) are studied. It was revealed some regularity of the structure of obtained thiones 4-6 by XRD and identified the conformational state cycloalkanoic rings and the reactivity of the methylene protons at C-6.

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Published

2022-03-17

Issue

Vol. 2 No. 4 (2016): Journal of Basic and Applied Research

Section

Original Article

License

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.

How to Cite

Synthesis and Study of Influence of the Methylene Group Quantity on the Structural Behavior of Polymethylene-Quinazolinethiones. (2022). Journal of Basic and Applied Research in Biomedicine, 2(4), 552-555. https://jbarbiomed.com/home/article/view/131

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