Antibiofilm and Quorum-sensing Agents Against Pseudomonas aeruginosa and Staphylococcus aureus: a Systematic Review of Preclinical Studies, 2022-2026
DOI:
https://doi.org/10.51152/jbarbiomed.v12i1.267Keywords:
Biofilm, Quorum sensing, Pseudomonas aeruginosa, Staphylococcus aureus, MRSA, Systematic review, AntivirulenceAbstract
Background: Biofilm formation and quorum sensing (QS) make Pseudomonas aeruginosa and Staphylococcus aureus hard to treat, and many preclinical agents are reported to act against both.
Objective: We mapped preclinical antibiofilm and anti-QS agents against these pathogens and graded how directly each study tested QS.
Methods: PubMed and Scopus were searched without a date limit (3,349 records). Eligible in vitro and in vivo studies were published from 2022 onward, tested an exogenous agent and named either organism in the title. Full-text data were extracted, each study received a QS evidence tier, and risk of bias was appraised with an adapted checklist (in vitro) or SYRCLE's tool (vertebrate studies); two reviewers verified the extraction.
Results: We included 252 studies, led by natural products (115). A QS assay in the target pathogen was present in 140 studies (56%), a surrogate reporter alone in 27 (11%), and 31 (12%) used a vertebrate infection model. In vitro risk of bias was low in 143, moderate in 93 and high in 16. No meta-analysis was done, and title-only organism matching may have missed studies.
Conclusion: Direct QS evidence is common for P. aeruginosa but thinner for S. aureus, and animal and cytotoxicity data are sparse.
References
Abbas, H.A., Shaker, G.H., Mosallam, F.M. and Gomaa, S.E., (2022). Novel silver metformin nano-structure to impede virulence of Staphylococcus aureus. AMB Express, 12(1), 84. https://doi.org/10.1186/s13568-022-01426-6
Abd El-Hamid, M.I., Ibrahim, D., Elazab, S.T., Gad, W.M., Shalaby, M., El-Neshwy, W.M., Alshahrani, M.A., Saif, A., Algendy, R.M., AlHarbi, M., Saleh, F.M., Alharthi, A. and Mohamed, E.A.A., (2024). Tackling strong biofilm and multi-virulent vancomycin-resistant Staphylococcus aureus via natural alkaloid-based porous nanoparticles: perspective towards near future eradication. Front Cell Infect Microbiol, 13, 1287426. https://doi.org/10.3389/fcimb.2023.1287426
Abdel Bar, F.M., Alossaimi, M.A., Elekhnawy, E., Alzeer, M.A.A., Abo Kamer, A., Moglad, E. and ElNaggar, M.H., (2022). Anti-Quorum Sensing and Anti-Biofilm Activity of Pelargonium × hortorum Root Extract against Pseudomonas aeruginosa: Combinatorial Effect of Catechin and Gallic Acid. Molecules, 27(22), 7841. https://doi.org/10.3390/molecules27227841
Abo-Dya, N.E., Agha, K.A., Abbas, H.A., Abu-Kull, M.E., Alahmdi, M.I. and Osman, N.A., (2022). Hybrid N-Acylcysteines as Dual-Acting Matrix Disruptive and Anti-Quorum Sensing Agents Fighting Pseudomonas aeruginosa Biofilms: Design, Synthesis, Molecular Docking Studies, and In Vitro Assays. ACS Omega, 7(23), 19879-19891. https://doi.org/10.1021/acsomega.2c01667
Aboulwafa, M.M., Mostafa, N.M., Youssef, F.S., Eldahshan, O.A. and Singab, A.N.B., (2025). Lavandula dentata leaves as potential natural antibiofilm agents against Pseudomonas aeruginosa. Sci Rep, 15(1), 8540. https://doi.org/10.1038/s41598-025-88824-5
Aflakian, F. and Hashemitabar, G., (2025). Biosynthesized silver nanoparticles at subinhibitory concentrations as inhibitors of quorum sensing, pathogenicity, and biofilm formation in Pseudomonas aeruginosa PAO1. Heliyon, 11(4), e42899. https://doi.org/10.1016/j.heliyon.2025.e42899
Aflakian, F., Rad, M., Hashemitabar, G., Lagzian, M. and Ramezani, M., (2022). Design and assessment of novel synthetic peptides to inhibit quorum sensing-dependent biofilm formation in Pseudomonas aeruginosa. Biofouling, 38(2), 131-146. https://doi.org/10.1080/08927014.2022.2028280
Aflakian, F., Rad, M., Hashemitabar, G., Lagzian, M. and Ramezani, M., (2023). Antibacterial and antibiofilm activities of novel antimicrobial peptides against Pseudomonas aeruginosa isolates from bovine mastitis. Bulg J Vet Med, 26(3), 351-360. https://doi.org/10.15547/bjvm.2021-0064
Ahmad, A.A.M., El-Naenaeey, E.Y., Aloufi, A.S., Khalifa, E.K., Khamis, T., Elmowalid, G.A. and El-Hamid, M.I.A., (2025). Thymoquinone/β-N-acetylglucosaminidase, a novel plant-derived combination, inhibited quorum sensing signaling pathways and disrupted biofilm in Staphylococcus aureus. Front Cell Infect Microbiol, 15, 1686764. https://doi.org/10.3389/fcimb.2025.1686764
Ahsan, A., Loh, T.C., Barnes, T.J. and Prestidge, C.A., (2026). Liquid crystalline nanoparticles for co-delivery of gentamicin and cinnamaldehyde: enhancing antibiofilm efficacy against Pseudomonas aeruginosa via quorum sensing inhibition. Int J Pharm, 702, 127218. https://doi.org/10.1016/j.ijpharm.2026.127218
Al-Helo, F.K., El-Banna, N., Qaralleh, H., Al-Limoun, M.O. and Khleifat, K., (2025). Quorum Sensing Inhibition and Virulence Factor Attenuation in Pseudomonas aeruginosa by Camphor. J Pharmacopuncture, 28(3), 229-239. https://doi.org/10.3831/KPI.2025.28.3.229
Al-Mijalli, S.H., El Hachlafi, N., Jeddi, M., Abdallah, E.M., Assaggaf, H., Qasem, A., Lee, L.H., Law, J.W., Aladhadh, M., Alnasser, S.M., Bouyahya, A. and Mrabti, H.N., (2023). Unveiling the volatile compounds and antibacterial mechanisms of action of Cupressus sempervirens L., against Bacillus subtilis and Pseudomonas aeruginosa. Biomed Pharmacother, 167, 115609. https://doi.org/10.1016/j.biopha.2023.115609
Al-Momani, H., Almasri, M., Al Balawi, D.A., Hamed, S., Albiss, B.A., Aldabaibeh, N., Ibrahim, L., Albalawi, H., Al Haj Mahmoud, S., Khasawneh, A.I., Kilani, M., Aldhafeeri, M., Bani-Hani, M., Wilcox, M., Pearson, J. and Ward, C., (2023). The efficacy of biosynthesized silver nanoparticles against Pseudomonas aeruginosa isolates from cystic fibrosis patients. Sci Rep, 13(1), 8876. https://doi.org/10.1038/s41598-023-35919-6
Al-Monofy, K.B., Abdelaziz, A.A., Abo-Kamar, A.M., Al-Madboly, L.A. and Farghali, M.H., (2025). In vitro and in vivo investigation of the antibacterial, antivirulence, and antiquorum sensing activities of β-carotene against difficult-to-treat resistant Pseudomonas aeruginosa. BMC Microbiol, 25(1), 501. https://doi.org/10.1186/s12866-025-04234-7
Al-Rabia, M.W., Asfour, H.Z., Alhakamy, N.A., Abdulaal, W.H., Ibrahim, T.S., Abbas, H.A., Salem, I.M., Hegazy, W.A.H. and Nazeih, S.I., (2024). Thymoquinone is a natural antibiofilm and pathogenicity attenuating agent in Pseudomonas aeruginosa. Front Cell Infect Microbiol, 14, 1382289. https://doi.org/10.3389/fcimb.2024.1382289
Albasri, H.M., Alfaraj, R., Radwan, A.A., Almaarik, B., Alagamy, M., Eltayb, E.K., Alomar, S., Aleanizy, F.S. and Alqahtani, F.Y., (2026). Anti-virulence activity of peptide C7-3 and its derivatives against Pseudomonas aeruginosa. Microb Pathog, 219, 108739. https://doi.org/10.1016/j.micpath.2026.108739
Alenazi, N.A., Aleanizy, F.S., Alqahtani, F.Y., Aldossari, A.A., Alanazi, M.M. and Alfaraj, R., (2024). Anti-quorum sensing activity of poly-amidoamine dendrimer generation 5 dendrimer loaded kinase inhibitor peptide against methicillin-resistant Staphylococcus aureus. Saudi Pharm J, 32(2), 101932. https://doi.org/10.1016/j.jsps.2023.101932
Alfaraj, R., Alkathiri, F.A., Alamri, L.A., Alnassar, N.B., Alanazi, S.H., Algarni, R.A., Alhabdan, N.S. and Abuthnain, R.A., (2025). Exploring the repurposed role of solithromycin as an antivirulence agent against Staphylococcus aureus and its resistant variants. Front Microbiol, 16, 1540997. https://doi.org/10.3389/fmicb.2025.1540997
Alipour-Khezri, E., Moqadami, A., Barzegar, A., Mahdavi, M., Skurnik, M. and Zarrini, G., (2024). Bacteriophages and Green Synthesized Zinc Oxide Nanoparticles in Combination Are Efficient against Biofilm Formation of Pseudomonas aeruginosa. Viruses, 16(6), 897. https://doi.org/10.3390/v16060897
Aljohani, A.M., El-Chami, C., Alhubail, M., Ledder, R.G., O'Neill, C.A. and McBain, A.J., (2023). Escherichia coli Nissle 1917 inhibits biofilm formation and mitigates virulence in Pseudomonas aeruginosa. Front Microbiol, 14, 1108273. https://doi.org/10.3389/fmicb.2023.1108273
Alossaimi, M.A., Abdel Bar, F.M., Elekhnawy, E. and ElNaggar, M.H., (2025). Antibacterial and antiviral potential of harmalacidine hydrochloride, a β-carboline alkaloid, against respiratory tract pathogens: Staphylococcus aureus and H1N1 influenza virus. PLoS One, 20(11), e0335014. https://doi.org/10.1371/journal.pone.0335014
Alyahyawy, O.Y., Munshi, R.M., Badr-Eldin, S.M., Aldawsari, H.M., Abualsunun, W., Abbas, H.A., Salem, I.M., Hegazy, W.A.H. and Nazeih, S.I., (2025). Reprofiling lamivudine as an antibiofilm and anti-pathogenic agent against Pseudomonas aeruginosa. AMB Express, 15(1), 33. https://doi.org/10.1186/s13568-025-01835-3
Ammar, Y.A., Ragab, A., Migahed, M.A., Al-Sharbasy, S., Salem, M.A., Riad, O.K.M., Selim, H.M.R.M., Abd-Elmaksoud, G.A. and Abusaif, M.S., (2023). Design, green synthesis, and quorum sensing quenching potential of novel 2-oxo-pyridines containing a thiophene/furan scaffold and targeting a LasR gene on P. aeruginosa. RSC Adv, 13(39), 27363-27384. https://doi.org/10.1039/d3ra04230h
Arami, N., Tajani, A.S., Hashemi, M., Rezaei, T., Ghodsi, R., Soheili, V. and Bazzaz, B.S.F., (2025). Targeted inhibition of PqsR in Pseudomonas aeruginosa PAO1 quorum-sensing network by chalcones as promising antibacterial compounds. Mol Biol Rep, 52(1), 175. https://doi.org/10.1007/s11033-025-10270-3
Azami, S., Arefian, E. and Kashef, N., (2022). Postbiotics of Lactobacillus casei target virulence and biofilm formation of Pseudomonas aeruginosa by modulating quorum sensing. Arch Microbiol, 204(2), 157. https://doi.org/10.1007/s00203-022-02770-8
Azimzadeh, M., Greco, G., Farmani, A., Nourian, A., Pourhajibagher, M., Taherkhani, A., Alikhani, M.Y. and Bahador, A., (2025). Biofilm inhibition of multidrug-resistant Pseudomonas aeruginosa using green-synthesized silver nanoparticles and colistin. Sci Rep, 15(1), 14993. https://doi.org/10.1038/s41598-025-00005-6
Azimzadeh, M., Greco, G., Farmani, A., Pourhajibagher, M., Taherkhani, A., Alikhani, M.Y. and Bahador, A., (2024). Synergistic effects of nano curcumin mediated photodynamic inactivation and nano-silver@colistin against Pseudomonas aeruginosa biofilms. Photodiagnosis Photodyn Ther, 45, 103971. https://doi.org/10.1016/j.pdpdt.2024.103971
Aziz, N., Rollando, Monica, E. and Susanto, F.X.H., (2024). Aromatherapeutic Antibacterials: Comparative Study of 40 Essential Oils and Their Biofilm Inhibition in Pseudomonas aeruginosa ATCC9027. HAYATI J Biosci, 31(3), 474-485. https://doi.org/10.4308/hjb.31.3.474-485
Badr-Eldin, S.M., Mubarak Aldawsari, H., Ahmed, O.A.A., Kotta, S., Abualsunun, W., Eshmawi, B.A., Khafagy, E.-S., Elbaramawi, S.S., Abbas, H.A., Hegazy, W.A.H. and Seleem, N.M., (2024). Utilization of zein nano-based system for promoting antibiofilm and anti-virulence activities of curcumin against Pseudomonas aeruginosa. Nanotechnol Rev, 13(1), 20230212. https://doi.org/10.1515/ntrev-2023-0212
Baird, R., Gogoi, D., Forde, L., Ahmed, S.W., Niu, M., Cavanagh, B., Fitzpatrick, F. and Reeves, E.P., (2026). Inhibition of Pseudomonas aeruginosa Biofilm Formation by Peptidyl-Arginine Deiminases 2 and 4. J Innate Immun, 18(1), 104-119. https://doi.org/10.1159/000550256
Bajire, S.K., Prabhu, A., Bhandary, Y.P., Irfan, K.M. and Shastry, R.P., (2023). 7-Ethoxycoumarin rescued Caenorhabditis elegans from infection of COPD derived clinical isolate Pseudomonas aeruginosa through virulence and biofilm inhibition via targeting Rhl and Pqs quorum sensing systems. World J Microbiol Biotechnol, 39(8), 208. https://doi.org/10.1007/s11274-023-03655-8
Balkrishna, A., Bhatti, S., Ngpoore, N.K., Jangid, H., Varshney, Y., Singh, R., Nain, P., Dev, R., Lochab, S. and Varshney, A., (2026). Disruption in Quorum-Sensing Circuits and Biofilm Matrix in Pseudomonas aeruginosa by Super-Critical CO2 Extracted Oleoresins From Rauvolfia serpentina Seeds Rescue Caenorhabditis elegans Model of Infection. FASEB J, 40(9), e71885. https://doi.org/10.1096/fj.202600762R
Balkrishna, A., Ngpoore, N.K., Bhatti, S., Varshney, Y., Kabdwal, M., Nain, P., Dev, R., Lochab, S. and Varshney, A., (2025). Linolenic acid-enriched supercritical carbon dioxide extract from seeds of Phyllanthus emblica L., a functional food with quorum quenching and anti-biofilm action, rescues Caenorhabditis elegans infection model from Pseudomonas aeruginosa. Appl Food Res, 5(2), 101244. https://doi.org/10.1016/j.afres.2025.101244
Ben Soltana, O., Barkallah, M., Rima, M., Bouaziz, T., El Garah, F., Abdelkafi, S. and Fendri, I., (2026). Antibiofilm potential of Chlorococcum dorsiventrale extracts against Pseudomonas aeruginosa: Biochemical and molecular insights. Microb Pathog, 214, 108399. https://doi.org/10.1016/j.micpath.2026.108399
Benaissa, A., Khadir, A., Tamfu, A.N., Kucukaydin, S., Latti, N., Benbelaïd, F., Boudiba, S., Eroglu, B., Bendahou, M. and Ceylan, O., (2024). Biofilm Disruption and Virulence Attenuation Effects of Essential Oil From Endemic Algerian Cistus munbyi (Cistaceae) Against Clinical Strains of Pseudomonas aeruginosa. Nat Prod Commun, 19(4), 1934578X241245234. https://doi.org/10.1177/1934578X241245234
Benaissa, A., Tamfu, A.N., Bouali, W., Bousselham, A., Medjdoub, H., Babali, B., Busra, A.E., Kucukaydin, S., Anouar, E.-H. and Ceylan, O., (2026). Biofilm disruption by citronellol and geraniol against clinical uropathogenic Pseudomonas aeruginosa: an integrated in vitro and in silico investigation. Mol Biol Rep, 53(1), 1269. https://doi.org/10.1007/s11033-026-12450-1
Bernabè, G., Marzaro, G., Di Pietra, G., Otero, A., Bellato, M., Pauletto, A., Scarpa, M., Sut, S., Chilin, A., Dall'Acqua, S., Brun, P. and Castagliuolo, I., (2022). A novel phenolic derivative inhibits AHL-dependent quorum sensing signaling in Pseudomonas aeruginosa. Front Pharmacol, 13, 996871. https://doi.org/10.3389/fphar.2022.996871
Bernabè, G., Marzaro, G., Shalata, M.E.M., Iosob, D., Inglima, V., Bellato, M., Castagliuolo, I. and Brun, P., (2025). Repurposing MK-8245 as a Quorum Sensing Inhibitor to Suppress Virulence and Potentiate Antibiotic Activity in Pseudomonas aeruginosa. Antibiotics, 14(11), 1116. https://doi.org/10.3390/antibiotics14111116
Bernal-Mercado, A.T., Juarez, J., Valdez, M.A., Ayala-Zavala, J.F., Del-Toro-Sánchez, C.L. and Encinas-Basurto, D., (2022). Hydrophobic Chitosan Nanoparticles Loaded with Carvacrol against Pseudomonas aeruginosa Biofilms. Molecules, 27(3), 699. https://doi.org/10.3390/molecules27030699
Bharti, S., Nayaka, S. and Kumar, R., (2022). Evaluation of some traditional therapeutic properties of Usnea longissima (Ascomycota, lichenized fungi): antimicrobial, antiquorum and antioxidant. J Microbiol Biotechnol Food Sci, 11(4), e3163. https://doi.org/10.55251/jmbfs.3163
Biswas, P., Bose, S. and Chakraborty, S., (2025a). Vitamin D3 potentiates antimicrobial and antibiofilm activities of streptomycin and thymoquinone against Pseudomonas aeruginosa. World J Microbiol Biotechnol, 41(3), 104. https://doi.org/10.1007/s11274-025-04304-y
Biswas, B.B., Islam, M.N., Dey, A., Bessho, Y. and Biswas, N.N., (2025b). Exploring Sonneratia caseolaris: A mangrove plant source for novel antibacterial compounds targeting quorum sensing and biofilm inhibition. The Microbe, 8, 100428. https://doi.org/10.1016/j.microb.2025.100428
Boles, B.R. and Horswill, A.R., (2008). Agr-mediated dispersal of Staphylococcus aureus biofilms. PLoS Pathog, 4, e1000052. https://doi.org/10.1371/journal.ppat.1000052
Boon, D., O'Rourke, B., Carmody, M., Woods, D.F., Gloe, A., Platero-Rochart, D., Sánchez-Murcia, P.A., McGlacken, G.P. and Reen, F.J., (2026). Coumarins Disrupt Cell-Cell Communication and Virulence in Priority Pathogens: Targeting the PQS Signalling System in Pseudomonas aeruginosa. Microb Biotechnol, 19(7), e70404. https://doi.org/10.1111/1751-7915.70404
Bugyna, L., Švantner, Ľ., Bilská, K., Pribus, M. and Bujdáková, H., (2025). Impact of Light-Activated Nanocomposite with Erythrosine B on agr Quorum Sensing System in Staphylococcus aureus. Antibiotics, 14(10), 1010. https://doi.org/10.3390/antibiotics14101010
Çevikbaş, H., Ulusoy, S. and Kaya Kinaytürk, N., (2024). Exploring rose absolute and phenylethyl alcohol as novel quorum sensing inhibitors in Pseudomonas aeruginosa and Chromobacterium violaceum. Sci Rep, 14(1), 15666. https://doi.org/10.1038/s41598-024-66888-z
Chadha, J., Ahuja, P., Mudgil, U., Khullar, L. and Harjai, K., (2024). Citral and triclosan synergistically silence quorum sensing and potentiate antivirulence response in Pseudomonas aeruginosa. Arch Microbiol, 206(7), 324. https://doi.org/10.1007/s00203-024-04059-4
Chaitanya, K.S., Yu, T.T., Chaudhari, H., Orenkonday, N., Kuthe, P.V., Kumar, N., Dey, R.J., Murugesan, S. and Gowri Chandra Sekhar, K.V., (2026). Discovery of triazole-tethered glycinate and propanoate derivatives bearing a thiolactone moiety as quorum sensing inhibitors of Pseudomonas aeruginosa: design, synthesis, biological evaluation, and biofilm inhibition. RSC Adv, 16(30), 27977-27993. https://doi.org/10.1039/d6ra00717a
Chakraborty, S., Baindara, P., Sharma, P., Jose, T.A., Manoharan, R. and Mandal, S.M., (2024). Anti-Biofilm Action of Cineole and Hypericum perforatum to Combat Pneumonia-Causing Drug-Resistant P. aeruginosa. Antibiotics, 13(8), 689. https://doi.org/10.3390/antibiotics13080689
Chen, H., Ji, P.C., Qi, Y.H., Chen, S.J., Wang, C.Y., Yang, Y.J., Zhao, X.Y. and Zhou, J.W., (2023). Inactivation of Pseudomonas aeruginosa biofilms by thymoquinone in combination with nisin. Front Microbiol, 13, 1029412. https://doi.org/10.3389/fmicb.2022.1029412
Chen, W., Shang, H., Zhang, W., Ma, Y., Guo, T., Ding, H., Jiang, J., Dong, J., Xu, F., Huang, Y. and Ma, S., (2026). Novel dual-targeting biofilm inhibitors for potentiating antibiotic efficacy against multidrug-resistant Pseudomonas aeruginosa infections. J Adv Res. https://doi.org/10.1016/j.jare.2026.05.032
Chen, H., Wu, L., Su, Y., Huang, Z., Wang, L., Xia, Z., Huang, H., Wang, W., Fang, J., Gu, Z., Sun, P. and Zheng, J., (2022). Inhibitory Effects of Compounds from Plumula nelumbinis on Biofilm and Quorum Sensing Against P. aeruginosa. Curr Microbiol, 79(8), 236. https://doi.org/10.1007/s00284-022-02914-5
Cinar Koc, A.S., Rizvanoglu, S.S., Eryilmaz, M., Demirci, B. and Onder, A., (2024). Chemical composition and bioactivities of essential oil from an endemic Salvia abscondtiflora Greuter & Burdet. Ankara Univ Eczacilik Fak Derg, 48(2), 586-596 https://doi.org/10.33483/jfpau.1416623
Coimbra, A., Miguel, S., Ribeiro, M., Coutinho, P., Silva, L., Duarte, A.P. and Ferreira, S., (2022). Thymus zygis Essential Oil: Phytochemical Characterization, Bioactivity Evaluation and Synergistic Effect with Antibiotics against Staphylococcus aureus. Antibiotics, 11(2), 146. https://doi.org/10.3390/antibiotics11020146
Curcic, J., Merendino, I., Matijasevic, D., Jovcic, B., Spriano, S. and Malesevic, M., (2025). ST1-YtnP lactonase from extreme environment: A promising antivirulence agent against multidrug-resistant Pseudomonas aeruginosa. Biomed Pharmacother, 190, 118443. https://doi.org/10.1016/j.biopha.2025.118443
Dahibhate, N.L., Shukla, S.K. and Kumar, K., (2022). A Cyclic Disulfide Diastereomer From Bioactive Fraction of Bruguiera gymnorhiza Shows Anti-Pseudomonas aeruginosa Activity. Front Pharmacol, 13, 890790. https://doi.org/10.3389/fphar.2022.890790
Danaraj, J., Uthirakrishnan, U., Kumaresan, S., Natarajan, P.K., Krishna, J., Perumal, A.S., Selvakumar, K., Karami, Z. and Pugazhendhi, A., (2024). Multifunctional application of seagrass-derived rosmarinic acid in mitigating biofilm and quorum-sensing virulence transcripts of methicillin-resistant Staphylococcus aureus. J Environ Chem Eng, 12(4), 113086. https://doi.org/10.1016/j.jece.2024.113086
Das, S., Paul, P., Dastidar, D.G., Chakraborty, P., Chatterjee, S., Sarkar, S., Maiti, D. and Tribedi, P., (2023). Piperine Exhibits Potential Antibiofilm Activity Against Pseudomonas aeruginosa by Accumulating Reactive Oxygen Species, Affecting Cell Surface Hydrophobicity and Quorum Sensing. Appl Biochem Biotechnol, 195(5), 3229-3256. https://doi.org/10.1007/s12010-022-04280-1
Das, H., Samanta, A.K., Kumar, S., Roychoudhury, P., Sarma, K., Akter, F., Subudhi, P.K. and Dutta, T.K., (2024a). Exploration of Antimicrobial, Antibiofilm and Antiquorum Sensing Activity of the Himalayan Yellow Raspberry (Rubus ellipticus) against Clinical Isolates of Escherichia coli and Staphylococcus aureus. Indian J Anim Res. https://doi.org/10.18805/IJAR.B-4514
Das, H., Samanta, A.K., Kumar, S., Roychoudhury, P., Sarma, K., Akter, F., Subudhi, P.K. and Dutta, T.K., (2024b). In vitro Antimicrobial, Antibiofilm and Antiquorum Sensing Activity of Indian Rhododendron (Melastoma malabathricum) against Clinical Isolates of Escherichia coli and Staphylococcus aureus. Indian J Anim Res. https://doi.org/10.18805/IJAR.B-4415
Debnath, G., Roy, R., Dastidar, D.G., Trivedi, S., Paul, P., Das, S., Chakraborty, P. and Tribedi, P., (2026). L-leucine shows promising antibiofilm potential against Pseudomonas aeruginosa. The Microbe, 11, 100737. https://doi.org/10.1016/j.microb.2026.100737
Dehbashi, S., Tahmasebi, H., Alikhani, M.Y., Vidal, J.E., Seifalian, A. and Arabestani, M.R., (2024). The healing effect of Pseudomonas Quinolone Signal (PQS) with co-infection of Staphylococcus aureus and Pseudomonas aeruginosa: A preclinical animal co-infection model. J Infect Public Health, 17(2), 329-338. https://doi.org/10.1016/j.jiph.2023.12.016
Deng, W., Lei, Y., Tang, X., Li, D., Liang, J., Luo, J., Liu, L., Zhang, W., Ye, L., Kong, J., Wang, K. and Chen, Z., (2022). DNase inhibits early biofilm formation in Pseudomonas aeruginosa- or Staphylococcus aureus-induced empyema models. Front Cell Infect Microbiol, 12, 917038. https://doi.org/10.3389/fcimb.2022.917038
Dey, P., De, R., Parai, D., Hossain, S.T. and Mukherjee, S.K., (2024). Enhanced antimicrobial activity of naringin-ciprofloxacin combination against Pseudomonas aeruginosa PAO1: Unveiling quorum-sensing mediated molecular mechanisms in biofilm formation and virulence. The Microbe, 5, 100171. https://doi.org/10.1016/j.microb.2024.100171
Dias, S.A., Pinto, S.N., Silva-Herdade, A.S., Cavaco, M., Neves, V., Tavares, L., Oliveira, M., Andreu, D., Coutinho, A., Castanho, M.A.R.B. and Veiga, A.S., (2023). Quantitative Imaging of the Action of vCPP2319, an Antimicrobial Peptide from a Viral Scaffold, against Staphylococcus aureus Biofilms of a Clinical Isolate. ACS Infect Dis, 9(10), 1889-1900. https://doi.org/10.1021/acsinfecdis.3c00195
Díaz, M.A., Vega-Hissi, E.G., Blázquez, M.A., Alberto, M.R. and Arena, M.E., (2024). Restraining Staphylococcus aureus Virulence Factors and Quorum Sensing through Lactic Acid Bacteria Supernatant Extracts. Antibiotics (Basel), 13(4), 297. https://doi.org/10.3390/antibiotics13040297
Djokic, L., Stankovic, N., Galic, I., Moric, I., Radakovic, N., Šegan, S., Pavic, A. and Senerovic, L., (2022). Novel Quorum Quenching YtnP Lactonase From Bacillus paralicheniformis Reduces Pseudomonas aeruginosa Virulence and Increases Antibiotic Efficacy in vivo. Front Microbiol, 13, 906312. https://doi.org/10.3389/fmicb.2022.906312
Dogheim, G.M., Shehat, M.G., Mahdy, D.M., Barakat, H.S., Abouelfetouh, A. and Ramadan, A.A., (2025). Antibacterial and anti-virulence activity of eco-friendly resveratrol-loaded lipid nanocapsules against methicillin-resistant Staphylococcus aureus. Sci Rep, 15(1), 14677. https://doi.org/10.1038/s41598-025-95343-w
Dou, J., Peng, H., Li, S., Shang, W., Yang, Y., Hu, X., Tan, L., Hu, Z., Wang, Y., Lin, F., Hu, Q., Xiao, C., Jiang, X., Li, M. and Rao, X., (2025). Homotypic Membrane Vesicle-Formulated VAN@ΔagrMVs for Methicillin-Resistant Staphylococcus aureus Biofilm Clearance. Biomater Res, 29, 0288. https://doi.org/10.34133/BMR.0288
Dündar, Y., Külahci, M.B., Kuyrukcu Öztürk, Ö. and Beyzi, E., (2025). Synthesis of Some Benzothiazolone Derivatives and Their Effects on Quorum Sensing. Fabad J Pharm Sci, 50(3), 721-732. https://doi.org/10.55262/fabadeczacilik.1787503
Elfaky, M.A., Elbaramawi, S.S., Eissa, A.G., Ibrahim, T.S., Khafagy, E.-S., Ali, M.A.M. and Hegazy, W.A.H., (2023). Drug repositioning: doxazosin attenuates the virulence factors and biofilm formation in Gram-negative bacteria. Appl Microbiol Biotechnol, 107(11), 3763-3778. https://doi.org/10.1007/s00253-023-12522-3
Eltayb, E.K., Alqahtani, F.Y., Alkahtani, H.M., Alsarra, I.A., Alfaraj, R. and Aleanizy, F.S., (2022). Attenuation of Pseudomonas aeruginosa Quorum Sensing Virulence of Biofilm and Pyocyanin by mBTL-Loaded Calcium Alginate Nanoparticles. Polymers, 14(17), 3655. https://doi.org/10.3390/polym14173655
Eshboev, F., Karakozova, M., Abdurakhmanov, J., Bobakulov, K., Dolimov, K., Abdurashidov, A., Baymirzaev, A., Makhnyov, A., Terenteva, E., Sasmakov, S., Piyakina, G., Egamberdieva, D., Nazarov, P.A. and Azimova, S., (2023). Antimicrobial and Cytotoxic Activities of the Secondary Metabolites of Endophytic Fungi Isolated from the Medicinal Plant Hyssopus officinalis. Antibiotics, 12(7), 1201. https://doi.org/10.3390/antibiotics12071201
Esnaashari, F., Alidoust, F.A., Jafari, N., Ghasemi, M., Asadi Rahmani, F., Sedaghat Safsari, S. and Zahmatkesh, H., (2026). Berberine-ZnO loaded chitosan nanoparticles inhibits biofilm formation in Pseudomonas aeruginosa PAO1 through targeting extracellular polymeric substances. BMC Biotechnol, 26(1), 26. https://doi.org/10.1186/s12896-026-01103-7
Esnaashari, F., Rostamnejad, D., Zahmatkesh, H. and Zamani, H., (2023). In vitro and in silico assessment of anti-quorum sensing activity of Naproxen against Pseudomonas aeruginosa. World J Microbiol Biotechnol, 39(9), 244. https://doi.org/10.1007/s11274-023-03690-5
Feng, L., Xu, M., Zeng, W., Zhang, X., Wang, S., Yao, Z., Zhou, T., Shi, S., Cao, J. and Chen, L., (2022). Evaluation of the antibacterial, antibiofilm, and anti-virulence effects of acetic acid and the related mechanisms on colistin-resistant Pseudomonas aeruginosa. BMC Microbiol, 22(1), 306. https://doi.org/10.1186/s12866-022-02716-6
Flemming, H.-C., Wingender, J., Szewzyk, U., Steinberg, P., Rice, S.A. and Kjelleberg, S., (2016). Biofilms: an emergent form of bacterial life. Nat Rev Microbiol, 14, 563–575. https://doi.org/10.1038/nrmicro.2016.94
Franco, D., Papasergi, S., Mediati, F., Guglielmino, S.P.P. and De Plano, L.M., (2026). Engineered Phage Modulates Quorum Sensing and Biofilm Formation in Pseudomonas aeruginosa. Microorganisms, 14(5), 1028. https://doi.org/10.3390/microorganisms14051028
Gaálová-Radochová, B., Kendra, S., Jordao, L., Kursawe, L., Kikhney, J., Moter, A. and Bujdáková, H., (2023). Effect of Quorum Sensing Molecule Farnesol on Mixed Biofilms of Candida albicans and Staphylococcus aureus. Antibiotics, 12(3), 441. https://doi.org/10.3390/antibiotics12030441
Ganesh, P.S., Veena, K., Senthil, R., Iswamy, K., Ponmalar, E.M., Mariappan, V., Girija, A.S.S., Vadivelu, J., Nagarajan, S., Challabathula, D. and Shankar, E.M., (2022). Biofilm-Associated Agr and Sar Quorum Sensing Systems of Staphylococcus aureus Are Inhibited by 3-Hydroxybenzoic Acid Derived from Illicium verum. ACS Omega, 7(17), 14653-14665. https://doi.org/10.1021/acsomega.1c07178
Ghosh, C., Das, M.C., Acharjee, S., Bhattacharjee, S., Sandhu, P., Kumari, M., Bhowmik, J., Ghosh, R., Banerjee, B., De, U.C., Akhter, Y. and Bhattacharjee, S., (2023a). Combating Staphylococcus aureus biofilm formation: the inhibitory potential of tormentic acid and 23-hydroxycorosolic acid. Arch Microbiol, 206(1), 25. https://doi.org/10.1007/s00203-023-03762-y
Ghosh, S., Lahiri, D., Nag, M., Dey, A., Sarkar, T., Biswas, R., Dutta, B., Mukherjee, D., Pati, S., Pattanaik, S. and Ray, R.R., (2023b). Analysis of Antibiofilm Activities of Bioactive Compounds from Honeyweed (Leonurus sibiricus) Against P. aeruginosa: an In Vitro and In Silico Approach. Appl Biochem Biotechnol, 195(9), 5312-5328. https://doi.org/10.1007/s12010-021-03797-1
Gómez, A.-C., Lyons, T., Mamat, U., Yero, D., Bravo, M., Daura, X., Elshafee, O., Brunke, S., Gahan, C.G.M., O'Driscoll, M., Gibert, I. and O'Sullivan, T.P., (2022). Synthesis and evaluation of novel furanones as biofilm inhibitors in opportunistic human pathogens. Eur J Med Chem, 242, 114678. https://doi.org/10.1016/j.ejmech.2022.114678
González-Cruz, J.A., González-Gallardo, G., Pérez-Velázquez, J.R., García-Mejía, C.D., Guevara-Vela, J.M., Oria-Hernández, J.A., Castillo-Villanueva, A., Rinza-Rocha, T. and Hernández-Vázquez, E., (2025). Synthesis of Urea-Containing Derivatives and their Application as Potential Anti-Methicillin-Resistant Staphylococcus aureus Agents. ChemMedChem, 20(19), e202500521. https://doi.org/10.1002/cmdc.202500521
Hacioglu, M., Yilmaz, F.N., Yetke, H.I. and Haciosmanoglu-Aldogan, E., (2024). Synergistic effects of quorum-sensing molecules and antimicrobials against Candida albicans and Pseudomonas aeruginosa biofilms: In vitro and in vivo studies. J Antimicrob Chemother, 79(11), 2828-2836. https://doi.org/10.1093/jac/dkae293
Hamid, S.J., Salih, T.M. and Aziz, T.A., (2025). Rational Design, Computational Analysis and Antibacterial Activities of Synthesized Peptide-Based Molecules Targeting Quorum Sensing-Dependent Biofilm Formation in Pseudomonas aeruginosa. Pharmaceuticals (Basel), 18(10), 1572. https://doi.org/10.3390/ph18101572
Hassan, R.K. and Al-Zubaidi, S.J.J., (2025). Synergistic Effect of Ciprofloxacin and Probiotics against Biofilm-Forming Pseudomonas aeruginosa. Bangladesh J Infect Dis, 12(2), 250-259. https://doi.org/10.3329/bjid.v12i2.86048
Hassan, W.H.B., Ghani, A.E.A., Taema, E.A., Yahya, G., El-Sadek, M.E., Mansour, B., Abdel-Halim, M.S. and Arafa, A.M., (2025). Chemical profile, virtual screening, and virulence-inhibiting properties of Sphagneticola trilobata L. essential oils against Pseudomonas aeruginosa. Sci Rep, 15(1), 11964. https://doi.org/10.1038/s41598-025-94486-0
He, X., Han, B., Wang, R., Guo, Y., Kao, R.Y.T., Li, H., Sun, H. and Xia, W., (2023). Dual-action gallium-flavonoid compounds for combating Pseudomonas aeruginosa infection. RSC Chem Biol, 4(10), 774-784. https://doi.org/10.1039/d3cb00033h
He, S., Wang, Y., Wang, W., Li, Y. and Zhang, Z., (2026). Synergistic Inhibitory Effect and Mechanism of Action of Cinnamaldehyde-Carvacrol Nanoemulsion on the Staphylococcus aureus and Escherichia coli Mixed Biofilms Formation. MicrobiologyOpen, 15(2), e70258. https://doi.org/10.1002/mbo3.70258
Hernández-Moreno, L.V., Pabón-Baquero, L.C., Prieto-Rodriguez, J.A. and Patiño-Ladino, O.J., (2023). Bioactive Compounds from P. pertomentellum That Regulate QS, Biofilm Formation and Virulence Factor Production of P. aeruginosa. Molecules, 28(17), 6181. https://doi.org/10.3390/molecules28176181
Hijazi, D.M., Dahabiyeh, L.A., Abdelrazig, S., Alqudah, D.A. and Al-Bakri, A.G., (2023). Micafungin effect on Pseudomonas aeruginosa metabolome, virulence and biofilm: potential quorum sensing inhibitor. AMB Express, 13(1), 20. https://doi.org/10.1186/s13568-023-01523-0
Homaei, S., Ghourchian, H. and Piri-Gharaghie, T., (2025). Antibacterial activity of alginate-casein nanocapsules containing allicin against multidrug-resistant Pseudomonas aeruginosa. Int Microbiol, 28(8), 2405-2422. https://doi.org/10.1007/s10123-025-00697-w
Hooijmans, C.R., Rovers, M.M., de Vries, R.B., Leenaars, M., Ritskes-Hoitinga, M. and Langendam, M.W., (2014). SYRCLE's risk of bias tool for animal studies. BMC Med Res Methodol, 14, 43. https://doi.org/10.1186/1471-2288-14-43
Hotterbeekx, A., Kumar-Singh, S., Goossens, H. and Malhotra-Kumar, S., (2017). In vivo and In vitro Interactions between Pseudomonas aeruginosa and Staphylococcus spp. Front Cell Infect Microbiol, 7, 106. https://doi.org/10.3389/fcimb.2017.00106
Hrynchuk, N., Zelena, L., Bukhtiarova, T., Vrynchanu, N., Ishchenko, L. and Vazhnichaya, E., (2022). Antibiofilm activity of 4-(adamantyl-1)-1-(1-aminobutyl) benzol against methicillin-resistant Staphylococcus aureus. Mikrobiol Zh, 84(3), 39-50. https://doi.org/10.15407/microbiolj84.03.039
Huang, Y., Chen, H., Wu, J., Huang, X., Zhang, Y., Ren, A., Wu, X., Huang, C., Xie, W., Zu, D., Shen, C., Xu, F., Chang, Y., Yang, L., Zhou, H., Sun, P., Xu, J., Liu, J., Li, S. and Zheng, J., (2026). Machine learning-driven discovery of aniline phenylacetate derivatives as LasR-targeted biofilm inhibitors against Pseudomonas aeruginosa infections. Acta Pharm Sin B, 16(10), 6852-6874. https://doi.org/10.1016/j.apsb.2026.03.048
Ilias, F., El Haci, I.A., El Ghali, F., Mrabet, R., Aifa, S. and Mnif, S., (2025). The effect of some Algerian plant essential oils on Pseudomonas aeruginosa biofilm formation and quorum sensing: in vitro and in silico studies. Nat Prod Res, 1-11. https://doi.org/10.1080/14786419.2025.2588794
Iobbi, V., Parisi, V., Bernabè, G., De Tommasi, N., Bisio, A. and Brun, P., (2023). Anti-Biofilm Activity of Carnosic Acid from Salvia rosmarinus against Methicillin-Resistant Staphylococcus aureus. Plants, 12(21), 3679. https://doi.org/10.3390/plants12213679
Ivanova, K., Ivanova, A., Hoyo, J., Pérez-Rafael, S. and Tzanov, T., (2022). Nano-Formulation Endows Quorum Quenching Enzyme-Antibiotic Hybrids with Improved Antibacterial and Antibiofilm Activities against Pseudomonas aeruginosa. Int J Mol Sci, 23(14), 7632. https://doi.org/10.3390/ijms23147632
Jaber, N.A. and Ghafil, J.A., (2026). Molecular insights into sub-inhibitory ceftriaxone-mediated modulation of Pseudomonas aeruginosa biofilm architecture, quorum sensing networks, and antibiotic-target docking interactions. Polim Med, 56(1), 65-74. https://doi.org/10.17219/pim/224596
Jana, D., Manna, T., Guchhait, K.C., Panja, S., Karmakar, A., Ballav, S., Hazra, S., Dey, S., Panda, A.K. and Ghosh, C., (2025). An investigation on anti-biofilm potential of Aegle marmelos fruit extract against multi-drug-resistant Staphylococcus aureus. BMC Complement Med Ther, 25(1), 334. https://doi.org/10.1186/s12906-025-05062-y
Jeong, G.-J., Park, D.-J., Kang, J.-H., Kim, S.-C., Ahn, Y.-J., Cho, K.-J., Khan, F., Jung, W.-K. and Kim, Y.-M., (2026). Bacterial biosurfactant-reinforced chitooligosaccharide/polyvinyl alcohol hydrogels accelerate methicillin-resistant Staphylococcus aureus-infected wound healing by attenuating its virulence factors. Asian J Pharm Sci. https://doi.org/10.1016/j.ajps.2026.101118
Jiang, Y., Tang, X., Wang, A., Yang, H., Jiang, X., Zhang, Y. and Lou, F., (2025). Shikonin-copper coordination nanoparticles for enhanced antibacterial and antibiofilm activity against Staphylococcus aureus. Sci Rep, 15(1), 39617. https://doi.org/10.1038/s41598-025-23269-4
Jin, Y., Lin, J., Shi, H., Jin, Y., Cao, Q., Chen, Y., Zou, Y., Tang, Y. and Li, Q., (2024). The active ingredients in Chinese peony pods synergize with antibiotics to inhibit MRSA growth and biofilm formation. Microbiol Res, 281, 127625. https://doi.org/10.1016/j.micres.2024.127625
Kamer, A.M.A., Abdelaziz, A.A., Al-Monofy, K.B. and Al-Madboly, L.A., (2023). Antibacterial, antibiofilm, and anti-quorum sensing activities of pyocyanin against methicillin-resistant Staphylococcus aureus: in vitro and in vivo study. BMC Microbiol, 23(1), 116. https://doi.org/10.1186/s12866-023-02861-6
Karaca, B., Kyalo Kilonzo, N., Korkmaz, Ş., Onar, O., Yıldırım, Ö. and Çöleri Cihan, A., (2025). The Dual Role of the Medicinal Mushroom Fomitopsis pinicola in Inhibiting Biofilm and Reducing Antibiotic Resistance of Methicillin-Resistant Staphylococcus aureus. Food Sci Nutr, 13(6), e70355. https://doi.org/10.1002/fsn3.70355
Karthikeyan, A., Thirugnanasambantham, M.K., Khan, F. and Mani, A.K., (2025). Bacteria-Inspired Synthesis of Silver-Doped Zinc Oxide Nanocomposites: A Novel Synergistic Approach in Controlling Biofilm and Quorum-Sensing-Regulated Virulence Factors in Pseudomonas aeruginosa. Antibiotics, 14(1), 59. https://doi.org/10.3390/antibiotics14010059
Karuppiah, V. and Seralathan, M., (2022). Quorum sensing inhibitory potential of vaccenic acid against Chromobacterium violaceum and methicillin-resistant Staphylococcus aureus. World J Microbiol Biotechnol, 38(8), 146. https://doi.org/10.1007/s11274-022-03335-z
Kasthuri, T., Barath, S., Nandhakumar, M. and Karutha Pandian, S., (2022). Proteomic profiling spotlights the molecular targets and the impact of the natural antivirulent umbelliferone on stress response, virulence factors, and the quorum sensing network of Pseudomonas aeruginosa. Front Cell Infect Microbiol, 12, 998540. https://doi.org/10.3389/fcimb.2022.998540
Khalid, S.J., Ain, Q., Khan, S.J., Jalil, A., Siddiqui, M.F., Ahmad, T., Badshah, M. and Adnan, F., (2022). Targeting Acyl Homoserine Lactones (AHLs) by the quorum quenching bacterial strains to control biofilm formation in Pseudomonas aeruginosa. Saudi J Biol Sci, 29(3), 1673-1682. https://doi.org/10.1016/j.sjbs.2021.10.064
Khan, S. and Jain, L., (2025). Inhibition of a Biofilm using Rhamnolipid obtained from a Moderate halophile Pseudomonas aeruginosa SH-6. Res J Pharm Technol, 12(18), 5640. https://doi.org/10.52711/0974-360X.2025.00814
Khan, P., Waheed, A., Azeem, M., Parveen, A., Yameen, M.A., Iqbal, J., Ali, M., Wang, S., Qayyum, S., Noor, A. and Naqvi, T.A., (2023). Essential Oil from Tagetes minuta Has Antiquorum Sensing and Antibiofilm Potential against Pseudomonas aeruginosa Strain PAO1. ACS Omega, 8(39), 35866-35873. https://doi.org/10.1021/acsomega.3c03507
Khayat, M.T., Abbas, H.A., Ibrahim, T.S., Khayyat, A.N., Alharbi, M., Darwish, K.M., Elhady, S.S., Khafagy, E.S., Safo, M.K. and Hegazy, W.A.H., (2022). Anti-Quorum Sensing Activities of Gliptins against Pseudomonas aeruginosa and Staphylococcus aureus. Biomedicines, 10(5), 1169. https://doi.org/10.3390/biomedicines10051169
Khdir, K.A. and Muhammed, S.M., (2025). Eco-friendly nanoparticles from Fusarium solani suppress biofilms and quorum sensing in Pseudomonas aeruginosa. Nanoscale Adv, 8(1), 80-96. https://doi.org/10.1039/d5na00898k
Kim, Y.G., Lee, J.H., Kim, S.H., Park, S.Y., Kim, Y.J., Ryu, C.M., Seo, H.W. and Lee, J.T., (2024). Inhibition of Biofilm Formation in Cutibacterium acnes, Staphylococcus aureus, and Candida albicans by the Phytopigment Shikonin. Int J Mol Sci, 25(4), 2426. https://doi.org/10.3390/ijms25042426
Kim, S., Lee, J.-H., Kim, Y.-G., Tan, Y. and Lee, J., (2022a). Hydroquinones Inhibit Biofilm Formation and Virulence Factor Production in Staphylococcus aureus. Int J Mol Sci, 23(18), 10683. https://doi.org/10.3390/ijms231810683
Kim, G.S., Park, C.R., Kim, J.E., Kim, H.K. and Kim, B.S., (2022b). Anti-Biofilm Effects of Torilis japonica Ethanol Extracts against Staphylococcus aureus. J Microbiol Biotechnol, 32(2), 220-227. https://doi.org/10.4014/jmb.2107.07053
Kim, T., Tabassum, N., Javaid, A. and Khan, F., (2025). Attenuation of Staphylococcus aureus Biofilms and Virulence by 3-Fluorocatechol. Antibiotics, 14(12), 1240. https://doi.org/10.3390/antibiotics14121240
Kiruthigha, T., Pathoor, N.N., Veeraragavan, G.R. and Ganesh, P.S., (2024). Exploring the Antimicrobial and Antibiofilm Activities of Luffa cylindrica against Pseudomonas aeruginosa and Enterococcus faecalis. Texila Int J Public Health, 12(3). https://doi.org/10.21522/TIJPH.2013.12.03.Art002
Knap, K., Kwieciń, K., Ohońska, D., Reczyńska-Kolman, K., Pamuła, E. and Brzychczy-Włoch, M., (2024). Synergistic effect of antibiotics, α-linolenic acid and solvent type against Staphylococcus aureus biofilm formation. Pharmacol Rep, 76(6), 1456-1469. https://doi.org/10.1007/s43440-024-00669-3
Koçöz, A.N. and Gökalsin, B., (2026). In vitro modulatory effects of lichen secondary metabolite vulpinic acid on pyoverdine production and quorum sensing-regulated traits in Pseudomonas aeruginosa. World J Microbiol Biotechnol, 42(3), 120. https://doi.org/10.1007/s11274-026-04886-1
Kong, J., Wang, Y., Yao, Z., Lin, Y., Zhang, Y., Han, Y., Zhou, T., Ye, J. and Cao, J., (2023). Eugenol works synergistically with colistin against colistin-resistant Pseudomonas aeruginosa and Klebsiella pneumoniae isolates by enhancing membrane permeability. Microbiol Spectr, 11(5), e03666-22. https://doi.org/10.1128/spectrum.03666-22
Koosehlar, E., Mohabatkar, H. and Behbahani, M., (2024). In Silico and In vitro Evaluations of the Antibacterial Activities of HIV-1 Nef Peptides against Pseudomonas aeruginosa. Int J Mol Cell Med. https://doi.org/10.22088/IJMCM.BUMS.13.1.46
Kumar, S., Paliya, B.S., Singh, B.N. and Agrawal, S., (2025). Biogenic Gold Nanocrystals Knock Down Pseudomonas aeruginosa Virulence via Quorum-Sensing and Antibiofilm Potential. Nanomaterials, 15(21), 1648. https://doi.org/10.3390/nano15211648
Kunz Coyne, A.J., Stamper, K., Bleick, C., Kebriaei, R., Lehman, S.M. and Rybak, M.J., (2024). Synergistic bactericidal effects of phage-enhanced antibiotic therapy against MRSA biofilms. Microbiol Spectr, 12(4), e03212-23. https://doi.org/10.1128/spectrum.03212-23
Lal, A.F., Gupta, P.S. and Yadav, P.K., (2023). In silico Study of Phenol Explorer Database as Potential Inhibitors of Quorum-Sensing Regulated Pathogenicity in Pseudomonas aeruginosa. Biomed Pharmacol J, 16(3), 1577-1590. https://doi.org/10.13005/bpj/2736
Lall, N., Kok, A.-M., Oosthuizen, C.B., Verma, S., Chassagne, F., Vo, P.H., Ho, K.-V., Lin, C.-H., Quave, C.L. and Twilley, D., (2025). Antibacterial and Antibiofilm Activity of 8-Hydroxyquinoline Derivatives Against Mycobacterium and Staphylococcus Species. Chem Biodivers, 22(12), e01892. https://doi.org/10.1002/cbdv.202501892
Langarudy, S.H.M., Sigarchian, M., Zahmatkesh, H., Esnaashari, F., Ghasemi, M.F., Zamani, H. and Rasti, B., (2025). Baicalin-Coated Zinc Oxide Nanoparticles: An Efficient Formulation to Combat Staphylococcus aureus Biofilm Formation and Quorum Sensing. ChemistrySelect, 10(41), e00315. https://doi.org/10.1002/slct.202500315
Lashaki, S.B., Moulavi, P., Ashrafi, F., Sharifi, A. and Asadi, S., (2025). Imipenem/cilastatin encapsulation in UIO-66-NH2 carrier as a new strategy for combating imipenem-resistant Pseudomonas aeruginosa isolates. J Glob Antimicrob Resist, 42, 15-27. https://doi.org/10.1016/j.jgar.2025.01.010
Lavan, S. and Athiappan, M., (2024). Anti-Quorum Sensing Efficacy of Mangifera indica Kernel Extract against Biofilm Formation in Pseudomonas aeruginosa. Res J Biotechnol, 19(2), 60. https://doi.org/10.25303/1902rjbt060075
Lavan, S., Varsha, M., Kannan, V., Anandan, R. and Athiappan, M., (2024). Synergistic Quorum quenching activity of Cinnamaldehyde against biofilm forming Pseudomonas aeruginosa. Res J Biotechnol, 19(6), 116. https://doi.org/10.25303/1906rjbt01160126
Le, T.T., Duong, H.T. and Nguyen, C.H., (2024). Characterization of in vitro antimicrobial activity of gyrophoric acid isolated from Parmotrema indicum on methicillin-resistant Staphylococcus aureus. J Appl Pharm Sci, 14(3), 045-054. https://doi.org/10.7324/JAPS.2024.163764
Le, K.Y. and Otto, M., (2015). Quorum-sensing regulation in staphylococci: an overview. Front Microbiol, 6, 1174. https://doi.org/10.3389/fmicb.2015.01174
Lee, J.-H., Kim, Y.-G. and Lee, J., (2022). Inhibition of Staphylococcus aureus Biofilm Formation and Virulence Factor Production by Petroselinic Acid and Other Unsaturated C18 Fatty Acids. Microbiol Spectr, 10(3), e01330-22. https://doi.org/10.1128/spectrum.01330-22
Lee, J. and Zhang, L., (2015). The hierarchy quorum sensing network in Pseudomonas aeruginosa. Protein Cell, 6, 26–41. https://doi.org/10.1007/s13238-014-0100-x
Leistikow, K.R., May, D.S., Suh, W.S., Asensio, G.V., Schaenzer, A.J., Currie, C.R. and Hristova, K.R., (2024). Bacillus subtilis-derived peptides disrupt quorum sensing and biofilm assembly in multidrug-resistant Staphylococcus aureus. mSystems, 9(8), e00712-24. https://doi.org/10.1128/msystems.00712-24
Leitão, M.M., Vieira, T.F., Sousa, S.F., Borges, F., Simões, M. and Borges, A., (2024). Dual action of benzaldehydes: Inhibiting quorum sensing and enhancing antibiotic efficacy for controlling Pseudomonas aeruginosa biofilms. Microb Pathog, 191, 106663. https://doi.org/10.1016/j.micpath.2024.106663
Lencova, S., Stiborova, H., Munzarova, M., Demnerova, K. and Zdenkova, K., (2022). Potential of Polyamide Nanofibers With Natamycin, Rosemary Extract, and Green Tea Extract in Active Food Packaging Development: Interactions With Food Pathogens and Assessment of Microbial Risks Elimination. Front Microbiol, 13, 857423. https://doi.org/10.3389/fmicb.2022.857423
Li, D.D., Li, H., Niu, W.X., Li, H. and Lee, J.H., (2026). A quorum sensing antagonist with dual bacterium- and host-directed anti-pathogenic activity against Pseudomonas aeruginosa. Virulence, 17(1), 2712735. https://doi.org/10.1080/21505594.2026.2712735
Li, D.-D., Wang, Y., Li, H., Niu, W.-X., Hong, J., Jung, J.H. and Lee, J.-H., (2025). Multifaceted Antipathogenic Activity of Two Novel Natural Products, Chermesiterpenoid B and Chermesiterpenoid B Seco Acid Methyl Ester, Against Pseudomonas aeruginosa. Microb Biotechnol, 18(2), e70101. https://doi.org/10.1111/1751-7915.70101
Liang, Y., Pan, Y., Li, Q., Wu, B. and Hu, M., (2022). RNA-seq-based transcriptomic analysis of AHL-induced biofilm and pyocyanin inhibition in Pseudomonas aeruginosa by Lactobacillus brevis. Int Microbiol, 25(3), 447-456. https://doi.org/10.1007/s10123-021-00228-3
Lima, E.M.F., Almeida, F.A., Sircili, M.P., Bueris, V. and Pinto, U.M., (2023). N-acetylcysteine (NAC) attenuates quorum sensing regulated phenotypes in Pseudomonas aeruginosa PAO1. Heliyon, 9(3), e14152. https://doi.org/10.1016/j.heliyon.2023.e14152
Lima, E.M.F., de Almeida, F.A. and Pinto, U.M., (2025). Exploring the antivirulence potential of phenolic compounds to inhibit quorum sensing in Pseudomonas aeruginosa. World J Microbiol Biotechnol, 41(2), 32. https://doi.org/10.1007/s11274-025-04255-4
Liu, J., Deng, Y., Wang, X., Luo, P., Ding, S., Zhang, W., Uddin, S., Li, H. and Li, Y., (2025). Novel PHL derivatives targeting quorum sensing: A strategy to combat Pseudomonas aeruginosa infections. Biofilm, 10, 100326. https://doi.org/10.1016/j.bioflm.2025.100326
Liu, Y., Su, S., Yu, M., Zhai, D., Hou, Y., Zhao, H., Ma, X., Jia, M., Xue, X. and Li, M., (2022). Pyrancoumarin derivative LP4C targeting of pyrimidine de novo synthesis pathway inhibits MRSA biofilm and virulence. Front Pharmacol, 13, 959736. https://doi.org/10.3389/fphar.2022.959736
Liu, X., Wang, Z., You, Z., Wang, W., Wang, Y., Wu, W., Peng, Y., Zhang, S., Yun, Y. and Zhang, J., (2024). Transcriptomic analysis of cell envelope inhibition by prodigiosin in methicillin-resistant Staphylococcus aureus. Front Microbiol, 15, 1333526. https://doi.org/10.3389/fmicb.2024.1333526
Lu, X., Wang, G., Xie, Y., Tang, W., Liu, B. and Zhang, J., (2023). Efflux pump inhibitor combined with ofloxacin decreases MRSA biofilm formation by regulating the gene expression of NorA and quorum sensing. RSC Adv, 13(4), 2707-2717. https://doi.org/10.1039/d2ra06696c
Luo, X., Wang, S., Yang, Y., Gao, R., Yuan, S., Yu, J., Liu, D. and Tan, X., (2026). Engineered Pseudomonas aeruginosa phages with quorum-quenching enzyme or depolymerase for inhibition of biofilm formation. Front Microbiol, 16, 1752980. https://doi.org/10.3389/fmicb.2025.1752980
Ma, X., Wang, B., Jiang, Y., Shi, Y., Liu, X. and Chen, Q., (2026). The inhibitory effect of mannosylerythritol lipids on Staphylococcus aureus biofilm via the Agr quorum-sensing system. Food Qual Saf, 10, fyag038. https://doi.org/10.1093/fqsafe/fyag038
Macho, M., Saha, S., Konert, G., Banerjee, A., Ewe, D., Hrouzek, P., Urajová, P. and Saurav, K., (2022). Screening of the Medicines for Malaria Venture Pandemic Response Box for Discovery of Antivirulent Drug against Pseudomonas aeruginosa. Microbiol Spectr, 10(6), e02232-22. https://doi.org/10.1128/spectrum.02232-22
Mahavy, C.E., Mol, A., Andrianarisoa, B., Duez, P., Jaziri, M.E., Baucher, M. and Rasamiravaka, T., (2022). The Xanthophyll Carotenoid Lutein Reduces the Invasive Potential of Pseudomonas aeruginosa and Increases Its Susceptibility to Tobramycin. Int J Mol Sci, 23(13), 7199. https://doi.org/10.3390/ijms23137199
Mahendrarajan, V., Lazarus, H. and Easwaran, N., (2024). Quorum quenching mediated biofilm impediment in Chromobacterium violaceum and Staphylococcus aureus by leaf extracts of Delonix elata. Heliyon, 10(11), e31898. https://doi.org/10.1016/j.heliyon.2024.e31898
Mahfouz, A.A., Abbas, H.A., Yousef, N. and Elgaml, A., (2026). Disarming Pseudomonas aeruginosa: repurposing vardenafil, valsartan, and olmesartan as anti-virulence and antibiofilm agents. Sci Rep, 16(1), 24455. https://doi.org/10.1038/s41598-026-64238-9
Maldonado-Pérez, H., Pinzón-Esquivel, J.P., Molina-Salinas, G.M., González-Sánchez, A.A., Dzib-Baak, H.E., Dzul-Beh, Á., Quintal-Novelo, C.J. and Uc-Cachón, A.H., (2025). Non- and Medium-Polar Fractions from Trametes villosa Inhibit Staphylococcus aureus Growth, Virulence, and Biofilm Formation. Microbiol Res, 16(12), 263. https://doi.org/10.3390/microbiolres16120263
Mandalari, G., Minuti, A., La Camera, E., Barreca, D., Romeo, O. and Nostro, A., (2023). Antimicrobial Susceptibility of Staphylococcus aureus Strains and Effect of Phloretin on Biofilm Formation. Curr Microbiol, 80(9), 303. https://doi.org/10.1007/s00284-023-03400-2
Mao, S., Li, Q., Yang, Z., Li, Y., Ye, X. and Wang, H., (2023a). Design, synthesis, and biological evaluation of benzoheterocyclic sulfoxide derivatives as quorum sensing inhibitors in Pseudomonas aeruginosa. J Enzyme Inhib Med Chem, 38(1), 2175820. https://doi.org/10.1080/14756366.2023.2175820
Mao, Y., Liu, P., Chen, H., Wang, Y., Li, C. and Wang, Q., (2023b). Baicalein Inhibits the Staphylococcus aureus Biofilm and the LuxS/AI-2 System in vitro. Infect Drug Resist, 16, 2861-2882. https://doi.org/10.2147/IDR.S406243
Maravić-Vlahoviček, G., Kindl, M., Andričević, K., Obranić, S. and Vladimir-Knežević, S., (2025). Modulatory Effects of Satureja montana L. Essential Oil on Biofilm Formation and Virulence Factors of Pseudomonas aeruginosa. Pharmaceuticals, 18(9), 1269. https://doi.org/10.3390/ph18091269
Maršík, D., Maťátková, O., Kolková, A. and Masák, J., (2024). Exploring the antimicrobial potential of chitosan nanoparticles: synthesis, characterization and impact on Pseudomonas aeruginosa virulence factors. Nanoscale Adv, 6(12), 3093-3105. https://doi.org/10.1039/d4na00064a
Martínez-Rodríguez, O.P., García-Contreras, R., Aguayo-Ortiz, R., Yeverino, I.R., Fajardo-Hernández, C.A., Patiño, A.D., Hernández Pérez, H.A., Hernández-Garnica, M. and Figueroa, M., (2025). Natural Products Inhibit Bacterial Growth and Modulate Quorum-Sensing Systems Las and Rhl in Pseudomonas aeruginosa PA14. Chem Biodivers, 22(12), e02040. https://doi.org/10.1002/cbdv.202502040
Masihzadeh, S., Amin, M. and Farshadzadeh, Z., (2023). In vitro and in vivo antibiofilm activity of the synthetic antimicrobial peptide WLBU2 against multiple drug resistant Pseudomonas aeruginosa strains. BMC Microbiol, 23(1), 131. https://doi.org/10.1186/s12866-023-02886-x
Matijasević, D., Malešević, M., Ćurčić, J., Pavlović, V.B., Milinčić, D.D., Lević, S.M., Stanisavljević, N., Dinić, M., Pešić, M.B. and Pantić, M., (2025). Inhibition of Pseudomonas aeruginosa quorum sensing-regulated behaviors by mushroom extracts. J Ethnopharmacol, 353, 120466. https://doi.org/10.1016/j.jep.2025.120466
Mazloumi Jourkouyeh, E., Taslimi Eshkalak, M., Faezi Ghasemi, M., Zahmatkesh, H., Rasti, B. and Zamani, H., (2024). Diclofenac Sodium and Gentamicin Co-Encapsulated PLGA Nanoparticles: Targeting Extracellular Matrix Components to Combat Biofilm Formation in Pseudomonas aeruginosa PAO1. J Clust Sci, 35(7), 2475-2488. https://doi.org/10.1007/s10876-024-02675-0
Meng, X., Ning, C., Lu, X., Kang, M., Yang, Y., Yu, Z., Wang, Y., Sun, Y. and Guo, H., (2026). The Effects of Baicalin in Combination with Cefotaxime on the Biofilm and Metabolic Reprogramming of Multidrug-Resistant Pseudomonas aeruginosa. Biomolecules, 16(4), 598. https://doi.org/10.3390/biom16040598
Mensah, C.N., Ampomah, G.B., Mensah, J.O., Gasu, E.N., Aboagye, C.I., Ekuadzi, E., Boadi, N.O. and Borquaye, L.S., (2022). N-alkylimidazole derivatives as potential inhibitors of quorum sensing in Pseudomonas aeruginosa. Heliyon, 8(12), e12581. https://doi.org/10.1016/j.heliyon.2022.e12581
Mirpour, M. and Zahmatkesh, H., (2024). Ketoprofen attenuates Las/Rhl quorum-sensing (QS) systems of Pseudomonas aeruginosa: molecular and docking studies. Mol Biol Rep, 51(1), 133. https://doi.org/10.1007/s11033-023-09071-3
Mitsuwan, W., Sornsenee, P. and Romyasamit, C., (2022). Lacticaseibacillus spp.; Probiotic candidates from Palmyra palm sugar possesses antimicrobial and anti-biofilm activities against methicillin-resistant Staphylococcus aureus. Vet World, 299-308. https://doi.org/10.14202/vetworld.2022.299-308
Mohan, A., Rajan, P.P., Kumar, P., Jayakumar, D., Mini, M., Asha, S. and Vaikkathillam, P., (2024). Theophylline as a quorum sensing and biofilm inhibitor in Pseudomonas aeruginosa and Chromobacterium violaceum. Int Microbiol, 27(5), 1457-1471. https://doi.org/10.1007/s10123-024-00487-w
Mühlen, S. and Dersch, P., (2016). Anti-virulence Strategies to Target Bacterial Infections. Curr Top Microbiol Immunol, 398, 147–183. https://doi.org/10.1007/82_2015_490
Murray, E.J., Dubern, J.-F., Chan, W.C., Chhabra, S.R. and Williams, P., (2022). A Pseudomonas aeruginosa PQS quorum-sensing system inhibitor with anti-staphylococcal activity sensitizes polymicrobial biofilms to tobramycin. Cell Chem Biol, 29(7), 1187-1199.e6. https://doi.org/10.1016/j.chembiol.2022.02.007
Naderi, K., Damavandi, M.S., Rezaei, A. and Havaei, S.A., (2025). Synergistic inhibition of agr quorum sensing in methicillin-resistant Staphylococcus aureus: a novel approach with natural compound encapsulation. Microbiol Spectr, 14(1), e01759-25. https://doi.org/10.1128/spectrum.01759-25
Nafee, N., Gaber, D.M., Abouelfetouh, A., Alseqely, M., Empting, M. and Schneider, M., (2024). Enzyme-Linked Lipid Nanocarriers for Coping Pseudomonal Pulmonary Infection. Would Nanocarriers Complement Biofilm Disruption or Pave Its Road?. Int J Nanomedicine, 19, 3861-3890. https://doi.org/10.2147/IJN.S445955
Nahar, S., Mahamud, A.G.M.S.U., Cho, A.J., Ashrafudoulla, M., Yu, J., Park, S.H. and Ha, S.D., (2025). Flavourzyme Suppresses Pseudomonas aeruginosa Biofilms by Targeting Motility, Quorum Sensing, and Virulence Genes. Curr Microbiol, 82(6), 240. https://doi.org/10.1007/s00284-025-04200-6
Nancy, K., Soumya, N. and Jayanthi, A., (2023). Bioactivity of Natural Polymers against Clinical Pathogens. Res J Biotechnol, 18(10), 235. https://doi.org/10.25303/1810rjbt2350240
Nath, M.J., Choudhury, S.R., Priyanka, Khan, S., Mandal, M. and Patel, S.K.S., (2026). Biofilm and Quorum-Sensing Inhibition by Novel Bacillus xiamenensis MM07 Endophytic Isolate from Paederia foetida to Combat Pseudomonas aeruginosa. Microbiol Res, 17(4), 65. https://doi.org/10.3390/microbiolres17040065
Nath, R., Lahiri, D., Nag, M., Mahapatra, D., Bhattacharya, M., Dutta, K. and Bhattacharya, D., (2025). Antibiofilm activity of exopolysaccharide-mediated ZnO nanoparticle against Pseudomonas aeruginosa biofilm. Naunyn Schmiedebergs Arch Pharmacol, 398(5), 5823-5834. https://doi.org/10.1007/s00210-024-03651-1
Ni, K.H., Cai, D., Lu, J. and Tian, J., (2022). Eugenol-Mediated Inhibition of Biofilm Formed by S. aureus: a Potent Organism for Pediatric Digestive System Diseases. Appl Biochem Biotechnol, 194(3), 1340-1358. https://doi.org/10.1007/s12010-021-03682-x
Nikki, Bhopale, A.J., Kharga, K., Yerramsetti, N., Kumar, R., Kumar, L. and Yadav, A.K., (2025). Design, synthesis, biological evaluation and in silico study of N-(Pyrimidin-2-yl)alkyl/arylamide derivatives as quorum sensing inhibitors against Pseudomonas aeruginosa. Mol Divers, 29(3), 2001-2016. https://doi.org/10.1007/s11030-024-10955-0
Ning, Y., Wang, X., Chen, P., Liu, S., Hu, J., Xiao, R., Li, L. and Lu, F., (2022). Targeted inhibition of methicillin-resistant Staphylococcus aureus biofilm formation by a graphene oxide-loaded aptamer/berberine bifunctional complex. Drug Deliv, 29(1), 1675-1683. https://doi.org/10.1080/10717544.2022.2079768
Noori, H.G., Tadjrobehkar, O. and Moazamian, E., (2023). Biofilm stimulating activity of solanidine and Solasodine in Pseudomonas aeruginosa. BMC Microbiol, 23(1), 208. https://doi.org/10.1186/s12866-023-02957-z
Nortje, N.Q., Aribisala, J.O., Pillay, C. and Sabiu, S., (2025). Molecular modelling and experimental validation of mangiferin and its related compounds as quorum sensing modulators of Pseudomonas aeruginosa. Arch Microbiol, 207(3), 53. https://doi.org/10.1007/s00203-025-04240-3
Nouh, H.S., El-Zawawy, N.A., El-Sapagh, S., Shalamesh, E.M. and Metwally, S.M., (2026). Harnessing the endophytic Clavispora lusitaniae for the biogenic synthesis of ethylene glycol-capped cerium oxide nanoparticles: a green approach to combat respiratory Pseudomonas aeruginosa. Microb Cell Fact, 25(1), 177. https://doi.org/10.1186/s12934-026-03091-x
Nurfauziah, P., Sultan, A.R., Helpia, H. and Aswad, M., (2026). Drug Repurposing of Antihistamines as Antibiotic Adjuvants to Inhibit Biofilm Formation in Methicillin-Resistant Staphylococcus aureus: An In Silico and In Vitro Approach. Trends Sci, 23(10), 13430. https://doi.org/10.48048/tis.2026.13430
Omar, A.M., Mohammad, K.A., Almalki, M., Abuelnaga, K.O. and Ibrahim, S.R.M., (2025). Integrated Experimental and Computational Discovery of Repurposed and Novel Inhibitors Targeting Staphylococcus aureus Biofilms. J Pharm Bioallied Sci, 17(3), 140-150. https://doi.org/10.4103/jpbs.jpbs_1389_25
Orababa, O.Q., Furner-Pardoe, J., Gale, A., Anonye, B., Ratcliff, J., Reddy, N., Maset, R.G., Harrington, N.E., Subhaskaran, S., Holden, S., Diggle, S.P., Corre, C. and Harrison, F., (2026). Uncovering the mechanism of action of a historical antimicrobial against S. aureus and A. baumannii. mSphere, 11(9), e00494-26. https://doi.org/10.1128/msphere.00494-26
Orlandi, V.T., Martegani, E., Trivellin, N., Bolognese, F. and Caruso, E., (2023). Photo-Inactivation of Staphylococcus aureus by Diaryl-Porphyrins. Antibiotics, 12(2), 228. https://doi.org/10.3390/antibiotics12020228
Owrang, M. and Gholami, A., (2024). Green-synthesized silver nanoparticles from Zataria multiflora as a promising strategy to target quorum sensing and biofilms in Pseudomonas aeruginosa. Heliyon, 10(19), e38395. https://doi.org/10.1016/j.heliyon.2024.e38395
Page, M.J., McKenzie, J.E., Bossuyt, P.M., et al., (2021). The PRISMA 2020 statement: an updated guideline for reporting systematic reviews. BMJ, 372, n71. https://doi.org/10.1136/bmj.n71
Patel, M., Siddiqui, A.J., Ashraf, S.A., Surti, M., Awadelkareem, A.M., Snoussi, M., Hamadou, W.S., Bardakci, F., Jamal, A., Jahan, S., Sachidanandan, M. and Adnan, M., (2022). Lactiplantibacillus plantarum-Derived Biosurfactant Attenuates Quorum Sensing-Mediated Virulence and Biofilm Formation in Pseudomonas aeruginosa and Chromobacterium violaceum. Microorganisms, 10(5), 1026. https://doi.org/10.3390/microorganisms10051026
Paunova-Krasteva, T., Dimitrova, P.D., Damyanova, T., Borisova, D., Leseva, M., Uzunova, I., Dimitrova, P.A., Ivanova, V., Trendafilova, A., Veleva, R. and Topouzova-Hristova, T., (2025). Interference of Pseudomonas aeruginosa Virulence Factors by Different Extracts from Inula Species. Pharmaceuticals, 18(12), 1824. https://doi.org/10.3390/ph18121824
Pei, Z.J., Li, C., Dai, W., Lou, Z., Sun, X., Wang, H., Khan, A.A. and Wan, C., (2023). The Anti-Biofilm Activity and Mechanism of Apigenin-7-O-Glucoside Against Staphylococcus aureus and Escherichia coli. Infect Drug Resist, 16, 2129-2140. https://doi.org/10.2147/IDR.S387157
Peppoloni, S., Colombari, B., Tagliazucchi, D., Odorici, A., Ventrucci, C., Meto, A. and Blasi, E., (2022). Attenuation of Pseudomonas aeruginosa Virulence by Pomegranate Peel Extract. Microorganisms, 10(12), 2500. https://doi.org/10.3390/microorganisms10122500
Piruthivraj, P., Maha Swetha, B.R., Anita Margret, A., Rosita, A.S., Rengasamy, P., Krishnamoorthy, R., Gatasheh, M.K., Elfaki Ibrahim, K., Ansari, S. and Vijayakumar, N., (2024). In vitro and in silico evaluation of anti-quorum sensing activity of marine red seaweeds Portieria hornemannii and Halymenia dilatata. J King Saud Univ Sci, 36(6), 103188. https://doi.org/10.1016/j.jksus.2024.103188
Porzio, E., Andrenacci, D. and Manco, G., (2023). Thermostable Lactonases Inhibit Pseudomonas aeruginosa Biofilm: Effect In Vitro and in Drosophila melanogaster Model of Chronic Infection. Int J Mol Sci, 24(23), 17028. https://doi.org/10.3390/ijms242317028
Pratiwi, S.U.T., Handayani, T.T., Hamzah, H., Sari, R., Damayanti, E., Allimi, H.S. and Nurhidayat, L., (2026). Quorum Quenching Potential of the Indigenous Kalimantan Fern Stenochlaena palustris Against Pseudomonas aeruginosa. Pak J Biol Sci, 29(2), 60-75. https://doi.org/10.3923/pjbs.2026.60.75
Prieto-Rodriguez, J.A., Hernández-Moreno, L.V., Pabón-Baquero, L.C., Patiño-Ladino, O.J. and Cuca-Suárez, L.E., (2026). Inhibition of Quorum Sensing-Controlled Virulence Factors and Biofilm in Pseudomonas aeruginosa by Piper Species. Antibiotics, 15(6), 627. https://doi.org/10.3390/antibiotics15060627
Proctor, C.R., Taggart, M.G., O'Hagan, B.M.G., McCarron, P.A., McCarthy, R.R. and Ternan, N.G., (2023). Furanone loaded aerogels are effective antibiofilm therapeutics in a model of chronic Pseudomonas aeruginosa wound infection. Biofilm, 5, 100128. https://doi.org/10.1016/j.bioflm.2023.100128
Qaralleh, H., (2023). Chemical Composition and Quorum Sensing Inhibitory Effect of Nepeta curviflora Methanolic Extract against ESBL Pseudomonas aeruginosa. J Pharmacopuncture, 26(4), 307-318. https://doi.org/10.3831/KPI.2023.26.4.307
Qaralleh, H., (2025a). Antivirulence potential of morin hydrate against Pseudomonas aeruginosa: Inhibition of biofilm formation, quorum sensing, and virulence gene expression. Microb Biosyst, 10(4). https://doi.org/10.21608/mb.2025.383488.1314
Qaralleh, H., (2025b). Attenuation of Quorum Sensing, Virulence Factors, and Biofilm Formation in Pseudomonas aeruginosa by Psidium guajava Leaf Extract. Jordan J Biol Sci, 18(2), 301-313. https://doi.org/10.54319/jjbs/180211
Qaralleh, H., Saghir, S.A.M., Al-Limoun, M.O., Dmor, S.M., Khleifat, K., Al-Ahmad, B.E.M., Al-Omari, L., Tabana, Y., Mothana, R.A., Al-Yousef, H.M. and Alqahtani, A.M., (2024). Effect of Matricaria aurea Essential Oils on Biofilm Development, Virulence Factors and Quorum Sensing-Dependent Genes of Pseudomonas aeruginosa. Pharmaceuticals, 17(3), 386. https://doi.org/10.3390/ph17030386
Qin, J., Yu, L., Peng, F., Ye, X., Li, G., Sun, C., Cheng, F., Peng, C. and Xie, X., (2023). Tannin extracted from Penthorum chinense Pursh, a potential drug with antimicrobial and antibiofilm effects against methicillin-sensitive Staphylococcus aureus and methicillin-resistant Staphylococcus aureus. Front Microbiol, 14, 1134207. https://doi.org/10.3389/fmicb.2023.1134207
Raghoonanadan, A., Dweba, Y., Aruwa, C.E. and Sabiu, S., (2025). Metabolomic fingerprinting, molecular modelling and experimental bioprospection of Helianthus annuus seed cultivars as Pseudomonas aeruginosa LasR modulators. Bioorg Chem, 154, 108046. https://doi.org/10.1016/j.bioorg.2024.108046
Ramesh, A., Kanagaraja, A., Gopinath, S.C.B. and Raman, P., (2026). Influence of nonpolar aliphatic amino acids on Pseudomonas aeruginosa for virulence factors production. Biotechnol Appl Biochem, 73(4), 1875-1884. https://doi.org/10.1002/bab.70139
Ramezani, H., Sazegar, H. and Rouhi, L., (2026). Rutin-luteolin flavonoid-encapsulated chitosan nanoparticles: a novel strategy to combat multidrug-resistant Pseudomonas aeruginosa. BMC Biotechnol, 26(1), 15. https://doi.org/10.1186/s12896-025-01087-w
Rasamiravaka, T., Mol, A., Duez, P., El Jaziri, M. and Baucher, M., (2026). Pentacyclic Triterpenoid Acids Inhibit the Expression of Quorum Sensing-Related Virulence Factors and the Formation of Biofilm in Pseudomonas aeruginosa PAO1. Antibiotics, 15(6), 623. https://doi.org/10.3390/antibiotics15060623
Rastgar, M.G., Rasti, B. and Zamani, H., (2022). Ibuprofen involves with the reduced expression of pelD and pelF in pathogenic Pseudomonas aeruginosa strains. Arch Microbiol, 204(6), 329. https://doi.org/10.1007/s00203-022-02930-w
Ray, R.R., (2024). Antibiofilm activities of the floral extract of Clitoria ternatea against the biofilm of two nosocomial pathogens, namely Staphylococcus aureus and Pseudomonas aeruginosa. Pharm Sci Asia, 51(2), 133-144. https://doi.org/10.29090/psa.2024.02.24.1347
Riahi, A., Mabudi, H., Tajbakhsh, E., Roomiani, L. and Momtaz, H., (2024). Optimizing chitosan derived from Metapenaeus affinis: a novel anti-biofilm agent against Pseudomonas aeruginosa. AMB Express, 14(1), 77. https://doi.org/10.1186/s13568-024-01732-1
Ricafrente, R.M.L. and Malalay, A.P., (2026). Synergistic Anti-quorum Sensing and Anti-biofilm Activities of Crude Terminalia catappa Leaf Extract Combined With Ciprofloxacin Against Pseudomonas aeruginosa. Cureus. 18(2): e103643. https://doi.org/10.7759/cureus.103643
Rossetto, V., Moore-Machacek, A., Woods, D.F., Galvão, H.M., Shanahan, R.M., Hickey, A., O'Leary, N., O'Gara, F., McGlacken, G.P. and Reen, F.J., (2023). Structural modification of the Pseudomonas aeruginosa alkylquinoline cell-cell communication signal, HHQ, leads to benzofuranoquinolines with anti-virulence behaviour in ESKAPE pathogens. Microbiology, 169(3), 001303. https://doi.org/10.1099/mic.0.001303
Saadati, F., Shahryari, S., Sani, N.M., Farajzadeh, D., Zahiri, H.S., Vali, H. and Noghabi, K.A., (2022). Effect of MA01 rhamnolipid on cell viability and expression of quorum-sensing (QS) genes involved in biofilm formation by methicillin-resistant Staphylococcus aureus. Sci Rep, 12(1), 14833. https://doi.org/10.1038/s41598-022-19103-w
Sabir, S., Das, T., Kuppusamy, R., Yu, T.T., Willcox, M.D., Black, D.S. and Kumar, N., (2023). Novel quinazolinone disulfide analogues as pqs quorum sensing inhibitors against Pseudomonas aeruginosa. Bioorg Chem, 130, 106226. https://doi.org/10.1016/j.bioorg.2022.106226
Sadeva, I.G.K.A., Wulandari, P.A., Prasetyo, A.V., Wahyuntika, L.P.N., Rahadi, P.N.K., Sasmana, I.G.A.P., Putra, I.M.R. and Darwinata, A.E., (2022). Analysis of antiquorum-sensing and antibiofilm activity by pomelo peel extract (Citrus maxima) on multidrug-resistance Pseudomonas aeruginosa. Biomedicine (Taipei), 12(4), 20-33. https://doi.org/10.37796/2211-8039.1364
Sagar, P.K., Sharma, P. and Singh, R., (2022). Inhibition of Quorum Sensing Regulated Virulence Factors and Biofilm Formation by Eucalyptus globulus against Multidrug-Resistant Pseudomonas aeruginosa. J Pharmacopuncture, 25(1), 37-45. https://doi.org/10.3831/KPI.2022.25.1.37
Sagar, P.K., Sharma, P. and Singh, R., (2024). Anti-Quorum Sensing and Anti-Biofilm Activity of Ginger (Zingiber officinale) Rhizomes against Multidrug-Resistant Clinical Isolates of Pseudomonas aeruginosa. Avicenna J Med Biotechnol. https://doi.org/10.18502/ajmb.v16i1.14171
Sajeevan, A., Andrew, D.J., Patra, T.N., Solomon, A.P. and Dandela, R., (2025). Novel synthesis and anti-pathogenic properties of ensifentrine and its intermediates against Pseudomonas aeruginosa. RSC Adv, 15(17), 13053-13063. https://doi.org/10.1039/d5ra01722j
Saleh, R.M. and Hassan, O.M., (2024). Antibacterial, Antibiofilm, and Quorum Quenching Properties of Biogenic Chitosan Silver Nanoparticles Against Staphylococcus aureus. BioNanoScience, 14(4), 4456-4468. https://doi.org/10.1007/s12668-024-01573-z
Salem, M.H., Azmy, A.F., Dishisha, T. and Dessouky, N., (2025). Pseudomonas aeruginosa clinical isolates in Egypt: phenotypic, genotypic, and antibiofilm assessment of Pluronic F-127. BMC Microbiol, 25(1), 245. https://doi.org/10.1186/s12866-025-03946-0
Samreen and Ahmad, I., (2025). Anti-infective synergy of Acacia nilotica bioactive fraction and methyl gallate with meropenem against pathogenicity of Pseudomonas aeruginosa. 3 Biotech, 15(7), 209. https://doi.org/10.1007/s13205-025-04372-9
Santajit, S., Tunyong, W., Horpet, D., Binmut, A., Kong-Ngoen, T., Wisessaowapak, C., Thavorasak, T., Pumirat, P. and Indrawattana, N., (2024). Unveiling the Antimicrobial, Anti-Biofilm, and Anti-Quorum-Sensing Potential of Paederia foetida Linn. Leaf Extract against Staphylococcus aureus: An Integrated In Vitro-In Silico Investigation. Antibiotics, 13(7), 613. https://doi.org/10.3390/antibiotics13070613
Schütz, C. and Empting, M., (2018). Targeting the Pseudomonas quinolone signal quorum sensing system for the discovery of novel anti-infective pathoblockers. Beilstein J Org Chem, 14, 2627–2645. https://doi.org/10.3762/bjoc.14.241
Setiawati, S., Sholikah, E.N., Nuryastuti, T., Jumina, J., Lisdiyanti, P. and Mustofa, M., (2024). The potency of Actinomycetes InaCC A758 against dual-species biofilms: Candida albicans and Staphylococcus aureus. J Appl Pharm Sci, 14(8), 188-196. https://doi.org/10.7324/JAPS.2024.144035
Shalmali, K. and Srividya, S., (2026). Investigating the anti-biofilm and wound healing capability of thyme essential oil in the context of multidrug-resistant Pseudomonas aeruginosa and pathogens associated with diabetic wounds. Res J Biotechnol, 7(21), 17. https://doi.org/10.25303/217rjbt017025
Shariati, A., Noei, M., Askarinia, M., Khoshbayan, A., Farahani, A. and Chegini, Z., (2024). Inhibitory effect of natural compounds on quorum sensing system in Pseudomonas aeruginosa: a helpful promise for managing biofilm community. Front Pharmacol, 15, 1350391. https://doi.org/10.3389/fphar.2024.1350391
Shevate, S., Bankar, A. and Patil, N., (2022). Assessment of quorum quenching activity of Serratia spp. isolated from plant rhizosphere against quorum sensing controlled biofilm-forming pathogens. J Microbiol Biotechnol Food Sci, 12(3), e5753. https://doi.org/10.55251/jmbfs.5753
Shilpi, J.A., Sarker, D.K., Seidel, V., Ali, M.T., Uddin, S.J., Basak, A., Chakraborty, S., Khairuzzaman, M., Nahar, A.U. and Abdus Salam, F.B., (2026). In vitro Antibiofilm Activity-directed In silico Identification of Natural Products Targeting Bacterial Biofilm Regulators SarA and LasR. Curr Pharm Biotechnol, 27(2), 154-167. https://doi.org/10.2174/0113892010348855241113031323
Shiralizadeh, S., Alikhani, M.S., Farmany, A., Azimzadeh, M., Shokoohizadeh, L., Pourhajibagher, M., Bahador, A. and Alikhani, M.Y., (2025). Effect of photodynamic therapy with imipenem and gentamicin-derived carbon dots on the expression of quorum sensing and virulence genes in Pseudomonas aeruginosa. BMC Microbiol, 25(1), 358. https://doi.org/10.1186/s12866-025-04083-4
Sierra-Quitian, A.G., Hernandez-Moreno, L.V., Pabon-Baquero, L.C., Prieto-Rodriguez, J.A. and Patiño-Ladino, O.J., (2023). Antiquorum and Antibiofilm Activities of Piper bogotense C. DC. against Pseudomonas aeruginosa and Identification of Bioactive Compounds. Plants, 12(9), 1901. https://doi.org/10.3390/plants12091901
Sim, M., Boya, B.R., Kim, Y.-G., Lee, J.-H. and Lee, J., (2025). Multi-Halogenated Indoles as Antimicrobial and Antivirulence Agents Against Drug-Resistant Staphylococcus aureus. Microb Biotechnol, 18(12), e70280. https://doi.org/10.1111/1751-7915.70280
Sim, M., Kim, Y.-G., Lee, J.-H. and Lee, J., (2024). Antibiofilm Activities of Multiple Halogenated Pyrimidines Against Staphylococcus aureus. Int J Mol Sci, 25(23), 12830. https://doi.org/10.3390/ijms252312830
Soni, M., Pathoor, N.N., Viswanathan, A., Veeraragavan, G.R. and Ganesh, P.S., (2024). Exploring the antimicrobial and antibiofilm activities of Artocarpus heterophyllus Lam. against Pseudomonas aeruginosa PAO1. World Acad Sci J, 6(5), 50. https://doi.org/10.3892/wasj.2024.265
Soukarieh, F., Williams, P., Stocks, M.J. and Cámara, M., (2018). Pseudomonas aeruginosa Quorum Sensing Systems as Drug Discovery Targets: Current Position and Future Perspectives. J Med Chem, 61, 10385–10402. https://doi.org/10.1021/acs.jmedchem.8b00540
Tajani, A.S., Amiri Tehranizadeh, Z., Pourmohammad, A., Pourmohammad, A., Iranshahi, M., Farhadi, F., Soheili, V. and Fazly Bazzaz, B.S., (2023). Anti-quorum sensing and antibiofilm activity of coumarin derivatives against Pseudomonas aeruginosa PAO1: Insights from in vitro and in silico studies. Iran J Basic Med Sci. https://doi.org/10.22038/IJBMS.2023.69016.15047
Touati, A., Ibrahim, N.A., Tighilt, L. and Idres, T., (2025). Anti-QS Strategies Against Pseudomonas aeruginosa Infections. Microorganisms, 13, 1838. https://doi.org/10.3390/microorganisms13081838
Tritripmongkol, P., Sangkanu, S., Boripun, R., Jeenkeawpieam, J., Chuprom, J., Nissapatorn, V., Pereira, M.L., Paul, A.K. and Mitsuwan, W., (2022). Robusta coffee extracts inhibit quorum sensing activity in Chromobacterium violaceum and reduce biofilms against Bacillus cereus and Staphylococcus aureus. Vet World, 2391-2398. https://doi.org/10.14202/vetworld.2022.2391-2398
Trognon, J., Vera, G., Rima, M., Stigliani, J.L., Amielet, L., El Hage, S., Lajoie, B., Roques, C. and El Garah, F., (2022). Investigation of Direct and Retro Chromone-2-Carboxamides Based Analogs of Pseudomonas aeruginosa Quorum Sensing Signal as New Anti-Biofilm Agents. Pharmaceuticals, 15(4), 417. https://doi.org/10.3390/ph15040417
Turkey, M. and Nazeam, J.A., (2025). Chromatographic fingerprinting and antibiofilm effect of Ziziphus jujuba fraction on Pseudomonas aeruginosa. AMB Express, 15(1), 79. https://doi.org/10.1186/s13568-025-01886-6
Turkey, M.S., Nazeam, J.A., Sherbiny, F.F., Alnasser, S.M., Abdo, W., Al-Noshokaty, T.M. and Abass, S.A., (2026). Bioactive goldenseal (Hydrastis canadensis) fraction suppresses multidrug-resistant Pseudomonas aeruginosa in a rat burn wound model: oral and topical administration. Sci Rep, 16(1), 27506. https://doi.org/10.1038/s41598-026-60341-z
Twomey, E., O'Connor, P.M., Coffey, A., Kiste, M., Guinane, C.M., Hill, C., Field, D. and Begley, M., (2024). Inhibition of Clinical MRSA Isolates by Coagulase Negative Staphylococci of Human Origin. Antibiotics, 13(4), 338. https://doi.org/10.3390/antibiotics13040338
van Gent, M.E., van der Reijden, T.J.K., Lennard, P.R., de Visser, A.W., Schonkeren-Ravensbergen, B., Dolezal, N., Cordfunke, R.A., Drijfhout, J.W. and Nibbering, P.H., (2022). Synergism between the Synthetic Antibacterial and Antibiofilm Peptide (SAAP)-148 and Halicin. Antibiotics, 11(5), 673. https://doi.org/10.3390/antibiotics11050673
Van Helden, S.R., Bleick, C.R., Holger, D.J., Ghali, A.E., Alexander, J., Kaye, K.S., Marshall, S.H., Rojas, L.J., Bonomo, R.A., Lehman, S.M. and Rybak, M.J., (2026). Impact of Pseudomonas aeruginosa biofilm exopolysaccharide composition on bacteriophage and bacteriophage-antibiotic combination activity. Antimicrob Agents Chemother, 70(1), e00925-25. https://doi.org/10.1128/aac.00925-25
Vetrivel, A., Vetrivel, P., Dhandapani, K., Natchimuthu, S., Ramasamy, M., Madheswaran, S. and Murugesan, R., (2023). Inhibition of biofilm formation, quorum sensing and virulence factor production in Pseudomonas aeruginosa PAO1 by selected LasR inhibitors. Int Microbiol, 26(4), 851-868. https://doi.org/10.1007/s10123-023-00338-0
Vuong, C., Saenz, H.L., Götz, F. and Otto, M., (2000). Impact of the agr quorum-sensing system on adherence to polystyrene in Staphylococcus aureus. J Infect Dis, 182, 1688–1693. https://doi.org/10.1086/317606
Wang, F., Ding, Z.W., Wang, Y.J., Xu, K.Z., Dar, O.I., Wang, M., Sethupathy, S., Liu, Y.Y. and Tang, S., (2025). Aquilaria sinensis essential oil inhibits biofilm formation and virulence of Staphylococcus aureus. Front Microbiol, 16, 1697407. https://doi.org/10.3389/fmicb.2025.1697407
Wang, X., Liu, S., Zhao, C., Zhang, X., Ning, Y. and Lu, F., (2022). Inhibition of Berberine on Methicillin-Resistant Staphylococcus aureus Biofilm Formation. Rev Bras Farmacogn, 32(3), 455-459. https://doi.org/10.1007/s43450-022-00242-0
Wang, Z., Sun, H., Yao, X., Li, D., Xu, L., Li, Y., Tian, S. and Hou, T., (2016). Comprehensive evaluation of ten docking programs on a diverse set of protein–ligand complexes: the prediction accuracy of sampling power and scoring power. Phys Chem Chem Phys, 18, 12964–12975. https://doi.org/10.1039/c6cp01555g
Wang, J., Yang, J.Y., Durairaj, P., Wen, W.H., Sabapathi, N., Yang, L., Wang, B. and Jia, A.Q., (2024). Discovery and evaluation of 3-(2-isocyanobenzyl)-1H-indole derivatives as potential quorum sensing inhibitors for the control of Pseudomonas aeruginosa infections in vitro. RSC Med Chem, 15(9), 3256-3271. https://doi.org/10.1039/d4md00354c
Warrier, A., Satyamoorthy, K. and Murali, T.S., (2025). Naringenin as a Potent Natural Biofilm Inhibitor of Pseudomonas aeruginosa in Diabetic Foot Ulcers Through lasR Competitive Inhibition. Curr Microbiol, 82(7), 305. https://doi.org/10.1007/s00284-025-04283-1
Wei, Z., Li, T., Gu, Y., Zhang, Q., Wang, E., Li, W., Wang, X., Li, Y. and Li, H., (2022). Design, Synthesis, and Biological Evaluation of N-Acyl-Homoserine Lactone Analogs of Quorum Sensing in Pseudomonas aeruginosa. Front Chem, 10, 948687. https://doi.org/10.3389/fchem.2022.948687
Wen, Z., Chen, C., Shang, Y., Fan, K., Li, P., Li, C., Zheng, J., Deng, Q. and Yu, Z., (2024a). Baohuoside I inhibits virulence of multidrug-resistant Staphylococcus aureus by targeting the transcription Staphylococcus accessory regulator factor SarZ. Phytomedicine, 130, 155590. https://doi.org/10.1016/j.phymed.2024.155590
Wen, F., Wu, Y., Yuan, Y., Yang, X., Ran, Q., Gan, X., Guo, Y., Wang, X., Chu, Y. and Zhao, K., (2024b). Discovery of psoralen as a quorum sensing inhibitor suppresses Pseudomonas aeruginosa virulence. Appl Microbiol Biotechnol, 108(1), 222. https://doi.org/10.1007/s00253-024-13067-9
WHO Bacterial Priority Pathogens List Advisory Group, Sati, H., Carrara, E., Savoldi, A., et al., (2025). The WHO Bacterial Priority Pathogens List 2024: a prioritisation study to guide research, development, and public health strategies against antimicrobial resistance. Lancet Infect Dis, 25, 1033–1043. https://doi.org/10.1016/S1473-3099(25)00118-5
Xie, J., Huang, Y., Chen, H., Xia, Z., Wang, L., Yu, X., Yang, J., Xu, J., Fan, H. and Zheng, J., (2026). Raphani Semen Extract Targets the las Quorum Sensing System to Suppress Pseudomonas aeruginosa Biofilm and Signal Molecule Production. Food Sci Nutr, 14(8), e72034. https://doi.org/10.1002/fsn3.72034
Yadav, A., Mahindru, I., Srivastava, N., Kumar, R., Jain, M., Kumar, L. and Yadav, A.K., (2026). Design, Synthesis, Biological Evaluation, and In Silico Study of N-(Pyrazin-2-yl)Alkyl/Aryl Amide Derivatives as Quorum Sensing Inhibitors Against Pseudomonas aeruginosa. Chem Biodivers, 23(1), e02287. https://doi.org/10.1002/cbdv.202502287
Yam, J.K.H., Tan, L.Z.W., Hong, Z., Salido, M.M.S., Woo, B.Y., Yong, A.M.H., Tan, C.A.Z., Li, S.F.Y., Yang, L., Givskov, M. and Chng, S.-S., (2023). Auranofin inhibits virulence pathways in Pseudomonas aeruginosa. Bioorg Med Chem, 79, 117167. https://doi.org/10.1016/j.bmc.2023.117167
Yan, X., Hou, S., Xing, C., Zhang, Y., Chang, J., Xiao, J. and Lin, F., (2024). Design, Synthesis, and Biological Evaluation of the Quorum-Sensing Inhibitors of Pseudomonas aeruginosa PAO1. Molecules, 29(10), 2211. https://doi.org/10.3390/molecules29102211
Ye, X., Mao, S., Li, Y., Yang, Z., Du, A. and Wang, H., (2023). Design, Synthesis, and Biological Evaluation of Phenyloxadiazole Sulfoxide Derivatives as Potent Pseudomonas aeruginosa Biofilm Inhibitors. Molecules, 28(9), 3879. https://doi.org/10.3390/molecules28093879
Ying, J., Guo, S., Pan, Y., Li, D., Tai, Y., Li, Y., Lin, Q., Pan, L., Huang, D., Xiao, H., Pan, R., Xu, X., Xie, J., Lou, Z. and Li, P., (2025). The role of cyano-phycocyanin as a quorum sensing inhibitor to attenuate Pseudomonas aeruginosa virulence. Front Cell Infect Microbiol, 15, 1624927. https://doi.org/10.3389/fcimb.2025.1624927
Yuan, Y., Yang, X., Zeng, Q., Li, H., Fu, R., Du, L., Liu, W., Zhang, Y., Zhou, X., Chu, Y., Zhang, X. and Zhao, K., (2022). Repurposing Dimetridazole and Ribavirin to disarm Pseudomonas aeruginosa virulence by targeting the quorum sensing system. Front Microbiol, 13, 978502. https://doi.org/10.3389/fmicb.2022.978502
Yue, Y., Chen, K., Sun, C., Ahmed, S. and Ojha, S.C., (2023). Antimicrobial peptidase lysostaphin at subinhibitory concentrations modulates staphylococcal adherence, biofilm formation, and toxin production. BMC Microbiol, 23(1), 311. https://doi.org/10.1186/s12866-023-03052-z
Zahmatkesh, H., Mirpour, M., Zamani, H., Rasti, B., Rahmani, F.A. and Padasht, N., (2022). Effect of samarium oxide nanoparticles on virulence factors and motility of multi-drug resistant Pseudomonas aeruginosa. World J Microbiol Biotechnol, 38(11), 209. https://doi.org/10.1007/s11274-022-03384-4
Zhang, Y., Liu, X., Wen, H., Cheng, Z., Zhang, Y., Zhang, H., Mi, Z. and Fan, X., (2023a). Anti-Biofilm Enzymes-Assisted Antibiotic Therapy against Burn Wound Infection by Pseudomonas aeruginosa. Antimicrob Agents Chemother, 67(7), e00307-23. https://doi.org/10.1128/aac.00307-23
Zhang, Y., Wei, W., Wen, H., Cheng, Z., Mi, Z., Zhang, J., Liu, X. and Fan, X., (2023b). Targeting Multidrug-Recalcitrant Pseudomonas aeruginosa Biofilms: Combined-Enzyme Treatment Enhances Antibiotic Efficacy. Antimicrob Agents Chemother, 67(1), e01358-22. https://doi.org/10.1128/aac.01358-22
Zhong, Z., Ma, Z., Zhang, Y., Gong, Y., Ge, Y., Yang, Y., Zhou, T. and Cao, J., (2026). Evaluation of the combined efficacy of carvone and colistin against colistin-resistant Pseudomonas aeruginosa: in vitro and in vivo studies. Microbiol Spectr, 14(6), e02307-25. https://doi.org/10.1128/spectrum.02307-25
Zhu, Y.Y., Jin, Q., Wang, Z.J., Wei, M.Z., Zu, W.B., Zhou, Z.S., Hu, B.Y., Zhao, Y.L., Qin, X.J. and Luo, X.D., (2025). Tripterhyponoid A from Tripterygium hypoglaucum Inhibiting MRSA by Multiple Mechanisms. Molecules, 30(12), 2539. https://doi.org/10.3390/molecules30122539
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