Chemical Transformation of Pyrido[2,3-d]Pyrimidin-4-ONES. 2. Selective Reduction of 2,3-Trimethylenepyrido[2,3-d]Pyrimidin-4-one by Sodium Borohydride.

Authors

  • Kh Khodjaniyazov S.Yunusov Institute of the Chemistry of Plant Substances AS of the Republic of Uzbekistan, 100170, Tashkent, M.Ulugbek st., 77, Uzbekistan.
  • A Mamadrakhimov A.S. Sadikov Institute of Biorganic Chemistry AS, Uzbekistan.
  • Kh Tadjimukhamedov Mirza Ulugbek National university of Uzbekistan, Uzbekistan.
  • M Levkovich S.Yunusov Institute of the Chemistry of Plant Substances AS of the Republic of Uzbekistan, 100170, Tashkent, M.Ulugbek st., 77, Uzbekistan.

Keywords:

2,3-trimethylene-1,2,3,4-tetrahydropyrido[2,3-d]pyrimidin-4-one, selective reduction, enantiomers, diastereomers, HPLC, chiral absorbent column.

Abstract

Reduction of 2,3-trimethylenepyrido[2,3-d]pyrimidin-4-one by sodium borohydride was investigated in an alcohol solution. Selective reduction of only a N1=C2 double bound of the initial compound was shown. The isomeric 2,3-trimethylene-1,2,3,4-tetrahydropyrido[2,3-d]-pyrimidin-4-ones are formed and quantitatively separated on HPLC with chiral adsorbent column. Theoretically formation of four optical isomers of 2,3-trimethylene-1,2,3,4-tetrahydropyrido[2,3-d]pyrimidin-4-ones are discussed.

Downloads

Published

2022-03-15