Synthesis, Characterization and Screening of Novel 5,6-Dihydroacridine Derivatives as Potent Antidiabetic and Antioxidant Agent

Authors

  • Kondeti Naveen Department of Pharmacy Practice, Rao’s College of Pharmacy, Chemudugunta, Nellore :
  • Karumudi Sai Department of Pharmacy Practice, Chalapathi Institute of Pharmaceutical Sciences, Guntur, India.
  • Kota Chandana Department of Pharmacy Practice, Chalapathi Institute of Pharmaceutical Sciences, Guntur, India.

Keywords:

Pyridine, Pyrimidine, Acridine, Antidiabetic, Antioxidant, FT-IR, 1H NMR, 13C NMR

Abstract

Acridine is an important nucleus in heterocyclic compounds which posses a wide spectrum of pharmacological activities. In this present work 10-Chloro-5,6-dihydro-12-phenylpyrimido[4,5-a]acridin-2-amine derivatives (PD-1 to PD-5) and 2-Amino-10-chloro-1,4,5,6-tetrahydro-12-phenylbenzo-[1,7] phenanthroline derivatives (PD-6 to PD-10) were synthesized from (E)-2-Benzylidene-7-chloro-3,4-dihydro-9-phenylacridin-1(2H)-one with guanidine carbonate and malononitrile. All the synthesized compounds have been characterized by using elemental analysis, FT-IR, 1H NMR, 13C NMR spectroscopy and further supported by mass spectroscopy. Purity of all the compounds has been checked on thin layer chromatographic plate and HPLC technique. All the synthesized compounds were tested for in vitro anti-diabetic and anti-oxidant activities. These compounds can be further exploited to get the potent lead compounds. The detailed synthesis and the anti-diabetic and anti-oxidant screening of the new compounds are reported.

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Published

2016-05-05