Deuterium Exchange of the α-Methylene Group Protons in the Quinazolones. III. Environment Influence on the Exchange Rate

Authors

  • G Levkovich Physical methods of Research Laboratory, Institute of the Chemistry of Plant Substances, Uzbek Academy of Sciences, Tashkent 100170, Uzbekistan.
  • Zh Elmuradov Organic Synthesis Department, Institute of the Chemistry of Plant Substances, Uzbek Academy of Sciences, Tashkent 100170, Uzbekistan.
  • M Shakhidoyatov Organic Synthesis Department, Institute of the Chemistry of Plant Substances, Uzbek Academy of Sciences, Tashkent 100170, Uzbekistan.
  • D Abdullaev Physical methods of Research Laboratory, Institute of the Chemistry of Plant Substances, Uzbek Academy of Sciences, Tashkent 100170, Uzbekistan.

Keywords:

deoxyvasicinone, proton exchange, deuterium exchange, kinetic 1H NMR spectroscopy

Abstract

By 1H NMR spectroscopy methods the exchange process of α-methylene group protons of deoxyvasicinone by deuterium atoms in the medium of CD3OD+NaOH and CD3OD+CD3COOD depending on NaOH concentration and temperature of the solution and CD3COOD have been investigated. It was shown that NaOH and CD3COOD have exchange initiator character, and their effect on the concentration are linear to D-exchange rate. The exponential dependence on temperature allowed us to determine the potential barrier of the initiation of the D- exchange process for deoxyvasicinone in the CD3COOD.

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Published

2022-03-15